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Current Oncology
Volume 23
Issue 4
10.3747/co.23.3051
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Prognostic Value of Pretreatment Circulating Neutrophils, Monocytes, and Lymphocytes on Outcomes in Lung Stereotactic Body Radiotherapy

by
M. Giuliani
1,*,
L.R. Sampson
2,
O. Wong
1,
J. Gay
1,
L.W. Le
2,
B.C.J. Cho
1,
A. Brade
1,
A. Sun
1,
A. Bezjak
1 and
A.J. Hope
1
1
Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada
2
Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, ON, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2016, 23(4), 362-368; https://doi.org/10.3747/co.23.3051
Submission received: 10 May 2016 / Revised: 9 June 2016 / Accepted: 7 July 2016 / Published: 1 August 2016

Abstract

Purpose: In the present study, we determined the association of pretreatment circulating neutrophils, monocytes, and lymphocytes with clinical outcomes after lung stereotactic body radiotherapy (sbrt). Methods: All patients with primary lung cancer and with a complete blood count within 3 months of lung sbrt from 2005 to 2012 were included. Overall survival (os) was calculated using the Kaplan–Meier method. Factors associated with os were investigated using univariable and multivariable Cox proportional hazards regression. Fine–Gray competing risk regression was performed to test the association of the neutrophil:lymphocyte (nlr) and monocyte:lymphocyte (mlr) ratios with two types of failure: disease-related failure and death, and death unrelated to disease. Results: Of the 299 sbrt patients identified, 122 were eligible for analysis. The median and range of the nlr and mlr were 3.0 (0.3–22.0) and 0.4 (0.1–1.9) respectively. On multivariable analysis, sex (p = 0.02), T stage (p = 0.04), and nlr (p < 0.01) were associated with os. On multivariable analysis, T stage (p < 0.01) and mlr (p < 0.01) were associated with disease-related failure; mlr (p = 0.03), nlr (p < 0.01), and sbrt dose of 48 Gy in 4 fractions (p = 0.03) and 54 Gy or 60 Gy in 3 fractions (p = 0.02) were associated with disease-unrelated death. Median survival was 4.3 years in the nlr ≤ 3 group (95% confidence interval: 3.5 to not reached) and 2.5 years in the nlr > 3 group (95% confidence interval: 1.7 to 4.8; p < 0.01). Conclusions: In lung sbrt patients, nlr and mlr are independently associated with os and disease-unrelated death. If validated, nlr and mlr could help to identify patients who would benefit most from sbrt.
Keywords: sbrt; sabr; neutrophils; lymphocytes; monocytes; hemoglobin; outcomes sbrt; sabr; neutrophils; lymphocytes; monocytes; hemoglobin; outcomes

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MDPI and ACS Style

Giuliani, M.; Sampson, L.R.; Wong, O.; Gay, J.; Le, L.W.; Cho, B.C.J.; Brade, A.; Sun, A.; Bezjak, A.; Hope, A.J. Prognostic Value of Pretreatment Circulating Neutrophils, Monocytes, and Lymphocytes on Outcomes in Lung Stereotactic Body Radiotherapy. Curr. Oncol. 2016, 23, 362-368. https://doi.org/10.3747/co.23.3051

AMA Style

Giuliani M, Sampson LR, Wong O, Gay J, Le LW, Cho BCJ, Brade A, Sun A, Bezjak A, Hope AJ. Prognostic Value of Pretreatment Circulating Neutrophils, Monocytes, and Lymphocytes on Outcomes in Lung Stereotactic Body Radiotherapy. Current Oncology. 2016; 23(4):362-368. https://doi.org/10.3747/co.23.3051

Chicago/Turabian Style

Giuliani, M., L.R. Sampson, O. Wong, J. Gay, L.W. Le, B.C.J. Cho, A. Brade, A. Sun, A. Bezjak, and A.J. Hope. 2016. "Prognostic Value of Pretreatment Circulating Neutrophils, Monocytes, and Lymphocytes on Outcomes in Lung Stereotactic Body Radiotherapy" Current Oncology 23, no. 4: 362-368. https://doi.org/10.3747/co.23.3051

APA Style

Giuliani, M., Sampson, L. R., Wong, O., Gay, J., Le, L. W., Cho, B. C. J., Brade, A., Sun, A., Bezjak, A., & Hope, A. J. (2016). Prognostic Value of Pretreatment Circulating Neutrophils, Monocytes, and Lymphocytes on Outcomes in Lung Stereotactic Body Radiotherapy. Current Oncology, 23(4), 362-368. https://doi.org/10.3747/co.23.3051

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