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Current Oncology
Volume 20
Issue 3
10.3747/co.20.1212
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Case Report

Spontaneous Regression of Metastatic Melanoma after Inoculation with Tetanus–Diphtheria–Pertussis Vaccine

by
T. Tran
1,*,
D. Burt
2,
L. Eapen
3 and
O.R. Keller
4
1
Internal Medicine, The Ottawa Hospital, Ottawa, ON, Canada
2
Riverside Court Medical Clinic, Ottawa, ON, Canada
3
Radiation Oncology, Ottawa Regional Cancer Centre, Ottawa, ON, Canada
4
Medical Oncology, Ottawa Regional Cancer Centre, Ottawa, ON, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2013, 20(3), 270-273; https://doi.org/10.3747/co.20.1212
Submission received: 8 May 2013 / Revised: 10 May 2013 / Accepted: 14 May 2013 / Published: 1 June 2013

Abstract

Spontaneous regression of metastatic melanoma is an exceedingly rare event, with only 76 well-documented cases in the literature since 1866. Here, we present the case of a patient who developed metastatic melanoma despite interferon therapy and who then achieved spontaneous regression shortly after a reaction to tetanus–diphtheria–pertussis vaccination. A common theme among these cases is the development of febrile illness before remission of the malignant disease. A brief overview of proposed mechanisms for these miraculous recoveries is presented, including a highlight on the potential role of the herv-k-mel viral marker, a nona- or decapeptide that appears in most melanomas, with homologies to peptides in pathogenic microorganisms.
Keywords: melanoma; regression; fever; tetanus; vaccination; cancer; pertussis; diphtheria melanoma; regression; fever; tetanus; vaccination; cancer; pertussis; diphtheria

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MDPI and ACS Style

Tran, T.; Burt, D.; Eapen, L.; Keller, O.R. Spontaneous Regression of Metastatic Melanoma after Inoculation with Tetanus–Diphtheria–Pertussis Vaccine. Curr. Oncol. 2013, 20, 270-273. https://doi.org/10.3747/co.20.1212

AMA Style

Tran T, Burt D, Eapen L, Keller OR. Spontaneous Regression of Metastatic Melanoma after Inoculation with Tetanus–Diphtheria–Pertussis Vaccine. Current Oncology. 2013; 20(3):270-273. https://doi.org/10.3747/co.20.1212

Chicago/Turabian Style

Tran, T., D. Burt, L. Eapen, and O.R. Keller. 2013. "Spontaneous Regression of Metastatic Melanoma after Inoculation with Tetanus–Diphtheria–Pertussis Vaccine" Current Oncology 20, no. 3: 270-273. https://doi.org/10.3747/co.20.1212

APA Style

Tran, T., Burt, D., Eapen, L., & Keller, O. R. (2013). Spontaneous Regression of Metastatic Melanoma after Inoculation with Tetanus–Diphtheria–Pertussis Vaccine. Current Oncology, 20(3), 270-273. https://doi.org/10.3747/co.20.1212

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