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Cardiovascular Medicine
Volume 13
Issue 11
10.4414/cvm.2010.01543
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Article

Kardiale Resynchronisationstherapie: «Real World»-Erfahrungen Eines Tertiären Zentrums in der Schweiz

by
David Hürlimann
1,*,
Jan Steffel
1,
Gligor Milosevic
1,
Nazmi Krasniqi
1,
Christiane Gruner
1,
Franz Oswald
1,
Mariette Rahn
2,
Volkmar Falk
2,
Georg Noll
1,
Thomas F. Lüscher
1,
Frank Ruschitzka
1 and
Johannes Holzmeister
1
1
Klinik für Kardiologie, Universitätsspital Zürich, Zürich, Switzerland
2
Klinik für Herz- und Gefässchirurgie, Universitätsspital Zürich, Zürich, Switzerland
*
Author to whom correspondence should be addressed.
Cardiovasc. Med. 2010, 13(11), 334; https://doi.org/10.4414/cvm.2010.01543
Submission received: 10 August 2010 / Revised: 10 September 2010 / Accepted: 10 October 2010 / Published: 10 November 2010
Versions Notes

Abstract

Background: Cardiac resynchronisation therapy (CRT) has become a mainstay in the treatment of patients with severe heart failure mainly due to large clinical trials demonstrating a reduction in morbidity and mortality. The aim of the present study was to evaluate the current practice of CRT in a “real world” setting in a large Swiss tertiary Center. Methods: All patients who underwent CRT-implantation (CRT-pacemaker or CRT-Defibrillators) at Zürich University Hospital between 2003 and 2010 were included in this retrospective analysis. Results: 208 patients (mean age 63.8 ± 10.9 years, 79.3% male) were included in the study. Ischemic etiology of heart failure was present in 49%; 79% of patients were in NYHA functional class III/IV. Mean QRS-duration was 153 ms (±30 ms) and mean ejection fraction 26 ± 8%. Median duration of hospital stay was two days. Perioperative complications were rare and comparable to those of large clinical trials. CRT lead to a considerable clinical and echocardiographic improvement. While NYHA functional class improved from 2.8 ± 0.6 to 2.1 ± 0.7 (p < 0.00001), left ventricular ejection fraction increased to 33 ± 11% (p < 0.00001) and enddiastolic volume index as well as endsystolic volume index were significantly reduced (p = 0.01 and p = 0.004, respectively). Conclusions: The present study demonstrates that CRT is effective and safe under ‚real world’ conditions. Even though CRT implantation rates in Switzerland are currently only average as compared the rest of Europe, positive study results as well as increasing familiarity and positive personal experience will likely result in an increasing proportion of heart failure patients to be evaluated for and treated with CRT.

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MDPI and ACS Style

Hürlimann, D.; Steffel, J.; Milosevic, G.; Krasniqi, N.; Gruner, C.; Oswald, F.; Rahn, M.; Falk, V.; Noll, G.; Lüscher, T.F.; et al. Kardiale Resynchronisationstherapie: «Real World»-Erfahrungen Eines Tertiären Zentrums in der Schweiz. Cardiovasc. Med. 2010, 13, 334. https://doi.org/10.4414/cvm.2010.01543

AMA Style

Hürlimann D, Steffel J, Milosevic G, Krasniqi N, Gruner C, Oswald F, Rahn M, Falk V, Noll G, Lüscher TF, et al. Kardiale Resynchronisationstherapie: «Real World»-Erfahrungen Eines Tertiären Zentrums in der Schweiz. Cardiovascular Medicine. 2010; 13(11):334. https://doi.org/10.4414/cvm.2010.01543

Chicago/Turabian Style

Hürlimann, David, Jan Steffel, Gligor Milosevic, Nazmi Krasniqi, Christiane Gruner, Franz Oswald, Mariette Rahn, Volkmar Falk, Georg Noll, Thomas F. Lüscher, and et al. 2010. "Kardiale Resynchronisationstherapie: «Real World»-Erfahrungen Eines Tertiären Zentrums in der Schweiz" Cardiovascular Medicine 13, no. 11: 334. https://doi.org/10.4414/cvm.2010.01543

APA Style

Hürlimann, D., Steffel, J., Milosevic, G., Krasniqi, N., Gruner, C., Oswald, F., Rahn, M., Falk, V., Noll, G., Lüscher, T. F., Ruschitzka, F., & Holzmeister, J. (2010). Kardiale Resynchronisationstherapie: «Real World»-Erfahrungen Eines Tertiären Zentrums in der Schweiz. Cardiovascular Medicine, 13(11), 334. https://doi.org/10.4414/cvm.2010.01543

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