Efficacy of Photobiomodulation in the Treatment of Cancer Chemotherapy-Induced Oral Mucositis: A Meta-Analysis with Trial Sequential Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Data Resources and Search Strategy
2.3. Study Selection
Inclusion Criteria
2.4. Data Extraction and Quality Assessment
2.5. Data Synthesis
3. Results
3.1. Study Selection
3.2. Characteristics of the Selected Studies
3.3. Risk of Bias
3.4. Reduction in the Severity of OM by PBM
3.5. Sensitivity Analysis
3.6. Trial Sequential Analysis
3.7. Duration of OM
3.8. Effect on Pain Relief
3.9. Adverse Effects
3.10. GRADE: Summary of Evidence
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Author | Intervention | Control | PBM Duration | Irradiation Time | Primary Outcome | OM Assessment | Secondary Outcomes | Other Outcomes |
---|---|---|---|---|---|---|---|---|
Kuhn 2007 [25] | Laser 830 nm, 100 mW | Sham | 5 days | N/A | Reduction in severity (OM grade) | NCI-CTCAE | OM duration | Nil |
Genot-Klastersky 2008 [28] | Visible laser + Infrared laser 100–500 mW | Sham | 3 days | 6 min | Reduction in severity (OM grade) | EORTC | OM progression | Esophageal OM |
Kuhn 2009 [26] | Laser 830 nm, 100 mW | Sham | 5 days | N/A | Reduction in severity (OM grade) | NCI-CTCAE v2 | OM duration | Nil |
Amadori 2016 [23] | Laser 830 nm, 150 mW | Sham | 4 days | 30 s | Reduction in severity (OM grade) | WHO | Pain score (VAS) | Nil |
Gobbo 2018 [24] | Laser 970 nm, 250 mW | Sham | 4 days | 25 s | Reduction in severity (OM grade) | WHO | OM grade on day 4 and 11 | Pain/analgesic use |
Legoute 2019 [27] | Laser 658 nm, 100 mW | Sham | 5 days | 40 s | Reduction in severity (OM grade) | WHO | Pain/consumption of analgesics | Nutritional status, compliance to cancer treatment, QoL |
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Al-Rudayni, A.H.M.; Gopinath, D.; Maharajan, M.K.; Veettil, S.K.; Menon, R.K. Efficacy of Photobiomodulation in the Treatment of Cancer Chemotherapy-Induced Oral Mucositis: A Meta-Analysis with Trial Sequential Analysis. Int. J. Environ. Res. Public Health 2021, 18, 7418. https://doi.org/10.3390/ijerph18147418
Al-Rudayni AHM, Gopinath D, Maharajan MK, Veettil SK, Menon RK. Efficacy of Photobiomodulation in the Treatment of Cancer Chemotherapy-Induced Oral Mucositis: A Meta-Analysis with Trial Sequential Analysis. International Journal of Environmental Research and Public Health. 2021; 18(14):7418. https://doi.org/10.3390/ijerph18147418
Chicago/Turabian StyleAl-Rudayni, Ali Hatem Manfi, Divya Gopinath, Mari Kannan Maharajan, Sajesh K. Veettil, and Rohit Kunnath Menon. 2021. "Efficacy of Photobiomodulation in the Treatment of Cancer Chemotherapy-Induced Oral Mucositis: A Meta-Analysis with Trial Sequential Analysis" International Journal of Environmental Research and Public Health 18, no. 14: 7418. https://doi.org/10.3390/ijerph18147418