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Implant Placement in Patients under Treatment with Rivaroxaban: A Retrospective Clinical Study

Department of Surgical, Medical, Molecular and of Critical Area Pathologies, Complex Operative Unit of Stomatology and Oral Surgery, University-Hospital of Pisa, University of Pisa, 56126 Pisa, Italy
Complex Operative Unit of Geriatrics, SS Filippo e Nicola Hospital, 67051 Avezzano, Italy
Unit of Oral Surgery and Implantology, Service of Maxillofacial and Buccal Surgery, Department of Surgery, Geneva University Hospitals, University of Geneva, 1205 Geneva, Switzerland
Department of Stomatology, Faculty of Dentistry, University of Seville, 41009 Seville, Spain
Department of Oral and Maxillofacial Surgery, Vaud University Hospital (CHUV Centre Hospitalier Universitaire Vaudois), 1011 Lausanne, Switzerland
Department of Periodontology and Dental Implantology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv 6997801, Israel
Private Practice, Innova Clinique, 28845 Domodossola, Italy
Department of Medical, Oral and Biotechnological Sciences, School of Dentistry, University of Chieti and Pescara, 66100 Chieti, Italy
Author to whom correspondence should be addressed.
The two authors contributed equally to the realization of this study.
Int. J. Environ. Res. Public Health 2020, 17(12), 4607;
Received: 5 June 2020 / Revised: 22 June 2020 / Accepted: 23 June 2020 / Published: 26 June 2020
(This article belongs to the Collection Modern Patient-Centered Dental Care)
The management of patients under treatment with Direct Oral Anticoagulants (DOACs) has led clinicians to deal with two clinical issues, such as the hemorrhagic risk in case of non-interruption or the risk of thromboembolism in case of suspension of the treatment. The primary aim of this retrospective study was to evaluate the incidence of perioperative bleeding events and healing complications in patients who were under treatment with Rivaroxaban and who received dental implants and immediate prosthetic restoration. Patients treated with Rivaroxaban (Xarelto 20 mg daily) and who needed implant rehabilitation were selected. Four to six implants were placed in mandibular healed sites or fresh extraction sockets. All patients, in agreement with their physicians, interrupted the medication for 24 h and received implants and immediate restorations. Twelve patients and 57 implants were analyzed in the study. No major postoperative bleeding events were reported. Three patients (25%) presented slight immediate postoperative bleeding controlled with compression only. The implant and prosthetic survival rate were both 100% after 1 year. Within the limitations of this study, multiple implant placement with an immediate loading can be performed without any significant complication with a 24 h discontinuation of Rivaroxaban, in conjunction with the patient’s physician. View Full-Text
Keywords: anticoagulants; implant placement; immediate loading anticoagulants; implant placement; immediate loading
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MDPI and ACS Style

Galletti, G.; Alfonsi, F.; Raffaele, A.; Valente, N.A.; Chatelain, S.; Kolerman, R.; Cinquini, C.; Romeggio, S.; Iezzi, G.; Barone, A. Implant Placement in Patients under Treatment with Rivaroxaban: A Retrospective Clinical Study. Int. J. Environ. Res. Public Health 2020, 17, 4607.

AMA Style

Galletti G, Alfonsi F, Raffaele A, Valente NA, Chatelain S, Kolerman R, Cinquini C, Romeggio S, Iezzi G, Barone A. Implant Placement in Patients under Treatment with Rivaroxaban: A Retrospective Clinical Study. International Journal of Environmental Research and Public Health. 2020; 17(12):4607.

Chicago/Turabian Style

Galletti, Guido, Fortunato Alfonsi, Angelo Raffaele, Nicola A. Valente, Sibylle Chatelain, Roni Kolerman, Chiara Cinquini, Stefano Romeggio, Giovanna Iezzi, and Antonio Barone. 2020. "Implant Placement in Patients under Treatment with Rivaroxaban: A Retrospective Clinical Study" International Journal of Environmental Research and Public Health 17, no. 12: 4607.

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