Next Article in Journal
Hyperspectral Data and Machine Learning for Estimating CDOM, Chlorophyll a, Diatoms, Green Algae and Turbidity
Previous Article in Journal
A Systematic Review of Access to General Healthcare Services for People with Disabilities in Low and Middle Income Countries
Previous Article in Special Issue
The Effect of Glyphosate on Human Sperm Motility and Sperm DNA Fragmentation
Article

Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS)

1
Department of Occupational Medicine and Public Health, the Faroes Hospital System, FO-100 Tórshavn, Faroe Islands
2
Center of Health Science, Faculty of Health Sciences, University of the Faroe Islands, FO-100 Tórshavn, Faroe Islands
3
Faculty of Science and Technology, University of the Faroe Islands, FO-100 Tórshavn, Faroe Islands
4
Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
5
Department of Environmental Medicine, University of Southern Denmark, 5000 Odense, Denmark
6
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2018, 15(9), 1880; https://doi.org/10.3390/ijerph15091880
Received: 27 July 2018 / Revised: 27 August 2018 / Accepted: 27 August 2018 / Published: 30 August 2018
Semen quality may be adversely affected by exposure to environmental chemicals such as polychlorinated biphenyls (PCBs) and perfluorinated alkylate substances (PFASs) that are persistent and may act as endocrine disrupting compounds. The aim of this study was to explore whether PCBs or PFASs exposure were associated with abnormalities in semen quality or reproductive hormones in Faroese men. This population based cross-sectional study includes 263 Faroese men (24–26 years) who delivered a semen sample for assessment of sperm concentration, total sperm count, semen volume, morphology and motility. A blood sample was drawn and analyzed for reproductive hormones, PCBs and PFASs. Exposure to ∑PCBs and perfluorooctane sulfonate (PFOS) was positively associated with sex hormone-binding globulin (SHBG) and luteinizing hormone (LH). In addition, total testosterone (T) was positively associated with ∑PCB. Both PCBs and PFOS appear to lead to increased SHBG, perhaps mediated via the liver. The higher total T associated with PCB may represent a compensatory adaption to elevated SHBG levels to maintain an unchanged free testosterone concentration. The positive association to LH for both PCBs and PFOS may indicate a direct adverse effect on the testosterone producing Leydig cells. View Full-Text
Keywords: semen quality; reproductive hormones; endocrine disturbing compounds; Faroe Islands semen quality; reproductive hormones; endocrine disturbing compounds; Faroe Islands
MDPI and ACS Style

Petersen, M.S.; Halling, J.; Jørgensen, N.; Nielsen, F.; Grandjean, P.; Jensen, T.K.; Weihe, P. Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS). Int. J. Environ. Res. Public Health 2018, 15, 1880. https://doi.org/10.3390/ijerph15091880

AMA Style

Petersen MS, Halling J, Jørgensen N, Nielsen F, Grandjean P, Jensen TK, Weihe P. Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS). International Journal of Environmental Research and Public Health. 2018; 15(9):1880. https://doi.org/10.3390/ijerph15091880

Chicago/Turabian Style

Petersen, Maria S.; Halling, Jónrit; Jørgensen, Niels; Nielsen, Flemming; Grandjean, Philippe; Jensen, Tina K.; Weihe, Pál. 2018. "Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS)" Int. J. Environ. Res. Public Health 15, no. 9: 1880. https://doi.org/10.3390/ijerph15091880

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop