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Open AccessArticle

The Risk of Breast Cancer in Women Using Menopausal Hormone Replacement Therapy in Taiwan

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Department of Family Medicine, Taipei Veterans General Hospital, No.201, Sec. 2, Shi-Pai Road, Taipei 11217, Taiwan
2
School of Medicine, National Yang-Ming University, No.155, Sec. 2, Linong Street, Taipei 11217, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Huixiao Hong
Int. J. Environ. Res. Public Health 2016, 13(5), 482; https://doi.org/10.3390/ijerph13050482
Received: 4 February 2016 / Revised: 3 May 2016 / Accepted: 6 May 2016 / Published: 11 May 2016
(This article belongs to the Special Issue Endocrine Disruptors and Public Health)
Menopausal hormone replacement therapy (HRT) increases the risk of breast cancer in Western countries; however, there are fewer reports from the Asian population, which has a lower incidence of breast cancer. A population-based retrospective cohort study was conducted by analyzing longitudinal National Health Insurance claim data of a 200,000-person national representative cohort. A total of 22,929 women aged ≥45 years in 1997 without previous diagnosis of breast cancer were enrolled and stratified into two birth cohorts born before or after 1933. HRT prescriptions were traced in outpatient data files and incident breast cancer cases were identified from 1997 to 2004. The Cox proportional hazards model was used to analyze breast cancer hazard ratio (HR). HRT users were censored after they discontinued HRT. The results showed that women born during 1933–1952 had a twofold increased risk of breast cancer (HR = 2.10, 95% CI = 1.47–3.00) compared with women born before 1933, when adjusted for HRT use. When adjusted for the birth-cohort difference, HRT users had significantly increased breast cancer HR versus non-users after four years of use (adjusted HR = 1.48, 95% CI = 1.03–2.13); the HR further increased to 1.95 (95% CI = 1.34–2.84) after eight years of use. In conclusion, a longer duration of current HRT use was associated with a higher risk of breast cancer independent of the birth-cohort difference. View Full-Text
Keywords: menopausal hormone replacement therapy; breast cancer; birth-cohort effect; National Health Insurance Research Database; Asian population menopausal hormone replacement therapy; breast cancer; birth-cohort effect; National Health Insurance Research Database; Asian population
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Liu, J.-Y.; Chen, T.-J.; Hwang, S.-J. The Risk of Breast Cancer in Women Using Menopausal Hormone Replacement Therapy in Taiwan. Int. J. Environ. Res. Public Health 2016, 13, 482.

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