Antiviral Activity of Graphene–Silver Nanocomposites against Non-Enveloped and Enveloped Viruses
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Department of Bioscience Technology, Chung Yuan Christian University, 200 Chung Pei Road, Chung Li District, Taoyuan City 32023, Taiwan
2
Graduate School of Biotechnology and Bioengineering, Yuan Ze University, 135 Yuan-Tung Road, Chung Li District, Taoyuan City 32003, Taiwan
3
Department of Chemical Engineering and Materials Science, Yuan Ze University, 135 Yuan-Tung Road, Chung Li District, Taoyuan City 32003, Taiwan
4
Division of General Pathology, Taoyuan General Hospital, Ministry of Health and Welfare, 1492 Zhongshan Road, Taoyuan City 33004, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Huang-Tsung Chang
Int. J. Environ. Res. Public Health 2016, 13(4), 430; https://doi.org/10.3390/ijerph13040430
Received: 18 February 2016 / Revised: 14 April 2016 / Accepted: 15 April 2016 / Published: 19 April 2016
(This article belongs to the Special Issue Nanomaterials-Based New Techniques, New Drugs, and Antibacterial Reagents)
The discovery of novel antiviral materials is important because many infectious diseases are caused by viruses. Silver nanoparticles have demonstrated strong antiviral activity, and graphene is a potential antimicrobial material due to its large surface area, high carrier mobility, and biocompatibility. No studies on the antiviral activity of nanomaterials on non-enveloped viruses have been reported. To investigate the antiviral activity of graphene oxide (GO) sheets and GO sheets with silver particles (GO-Ag) against enveloped and non-enveloped viruses, feline coronavirus (FCoV) with an envelope and infectious bursal disease virus (IBDV) without an envelope were chosen. The morphology and sizes of GO and GO-Ag were characterized by transmission, scanning electron microscopy, and X-ray diffraction. A virus inhibition assay was used to identify the antiviral activity of GO and GO-Ag. Go-Ag inhibited 25% of infection by FCoV and 23% by IBDV, whereas GO only inhibited 16% of infection by FCoV but showed no antiviral activity against the infection by IBDV. Further application of GO and GO-Ag can be considered for personal protection equipment to decrease the transmission of viruses.
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Keywords:
graphene oxide; silver nanoparticle; feline coronavirus; infectious bursal disease virus; enveloped virus; non-enveloped virus
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MDPI and ACS Style
Chen, Y.-N.; Hsueh, Y.-H.; Hsieh, C.-T.; Tzou, D.-Y.; Chang, P.-L. Antiviral Activity of Graphene–Silver Nanocomposites against Non-Enveloped and Enveloped Viruses. Int. J. Environ. Res. Public Health 2016, 13, 430.
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