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Mar. Drugs 2011, 9(9), 1502-1509;

A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities

Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
Graduate University of Chinese Academy of Sciences, Beijing 100049, China
Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen D-37077, Germany
Yantai Institute of China Agricultural University, China Agricultural University, Yantai 264670, China
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
Author to whom correspondence should be addressed.
Received: 12 July 2011 / Revised: 17 August 2011 / Accepted: 19 August 2011 / Published: 9 September 2011
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A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR (1H–1H COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene showed cytotoxicity against human lung adenocarcinoma cell line A549. View Full-Text
Keywords: Streptomyces; anthracene; structure establishment; cytotoxicity Streptomyces; anthracene; structure establishment; cytotoxicity

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Zhang, H.; Wang, H.; Cui, H.; Li, Z.; Xie, Z.; Pu, Y.; Li, F.; Qin, S. A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities. Mar. Drugs 2011, 9, 1502-1509.

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