Next Article in Journal
Effect of Elatol, Isolated from Red Seaweed Laurencia dendroidea, on Leishmania amazonensis
Previous Article in Journal
Marine Antitumor Drugs: Status, Shortfalls and Strategies
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2010, 8(10), 2721-2732; https://doi.org/10.3390/md8102721

Toxic Effects of Domoic Acid in the Seabream Sparus aurata

1
CIIMAR/CIMAR, Centro Interdisciplinar de Investigação Marinha e Ambiental, Rua dos Bragas 177-289, 4150-123 Porto, Portugal
2
Laboratório de Biologia Celular, Instituto de Ciências Biomédicas Abel Salazar, ICBAS, Lg. Abel Salazar 2, 4099-003 Porto, Portugal
3
Departamento de Química Analítica, Facultad de Química, As Lagoas Marcosende C.P. 36210, Spain
4
Laboratório de Histologia e Embriologia, Instituto de Ciências Biomédicas Abel Salazar, ICBAS, Lg. Abel Salazar 2, 4099-003 Porto, Portugal
5
Departamento de Biologia, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 4169-007 Porto, Portugal
*
Author to whom correspondence should be addressed.
Received: 8 September 2010 / Revised: 7 October 2010 / Accepted: 14 October 2010 / Published: 15 October 2010
Full-Text   |   PDF [404 KB, uploaded 24 February 2015]   |  

Abstract

Neurotoxicity induced in fish by domoic acid (DA) was assessed with respect to occurrence of neurotoxic signs, lethality, and histopathology by light microscopy. Sparus aurata were exposed to a single dose of DA by intraperitoneal (i.p.) injection of 0, 0.45, 0.9, and 9.0 mg DA kg−1 bw. Mortality (66.67 ± 16.67%) was only observed in dose of 9.0 mg kg−1 bw. Signs of neurological toxicity were detected for the doses of 0.9 and 9.0 mg DA kg−1 bw. Furthermore, the mean concentrations (±SD) of DA detected by HPLC-UV in extracts of brain after exposure to 9.0 mg DA kg−1 bw were 0.61 ± 0.01, 0.96 ± 0.00, and 0.36 ± 0.01 mg DA kg−1 tissue at 1, 2, and 4 hours. The lack of major permanent brain damage in S. aurata, and reversibility of neurotoxic signs, suggest that lower susceptibility to DA or neuronal recovery occurs in affected individuals. View Full-Text
Keywords: domoic acid; amnesic shellfish poisoning; Pseudo-nitzschia; algal neurotoxin; Sparus aurata domoic acid; amnesic shellfish poisoning; Pseudo-nitzschia; algal neurotoxin; Sparus aurata
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Nogueira, I.; Lobo-da-Cunha, A.; Afonso, A.; Rivera, S.; Azevedo, J.; Monteiro, R.; Cervantes, R.; Gago-Martinez, A.; Vasconcelos, V. Toxic Effects of Domoic Acid in the Seabream Sparus aurata. Mar. Drugs 2010, 8, 2721-2732.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top