The Effect of Eating Sea Cucumber Jelly on Candida Load in the Oral Cavity of Elderly Individuals in a Nursing Home
by
Akira Yano 1,*, Akiko Abe 2, Fumie Aizawa 2, Hidetoshi Yamada 1, Kentaro Minami 2, Miki Matsui 2 and Mitsuo Kishi 2
Akira Yano 1,*, Akiko Abe 2, Fumie Aizawa 2, Hidetoshi Yamada 1, Kentaro Minami 2, Miki Matsui 2 and Mitsuo Kishi 2
1
Iwate Biotechnology Research Center, Kitakami, Iwate 024-0003, Japan
2
Division of Oral Health, Iwate Medical University School of Dentistry, Morioka 020-8505, Japan
*
Author to whom correspondence should be addressed.
Mar. Drugs 2013, 11(12), 4993-5007; https://doi.org/10.3390/md11124993
Received: 9 October 2013 / Revised: 15 November 2013 / Accepted: 26 November 2013 / Published: 11 December 2013
We conducted a double-blind randomized controlled study of elderly individuals in a nursing home to investigate the effect of the consumption of jelly containing sea cucumber on their oral Candida load. The jelly contained a hydrolysate of the sea cucumber Stichopus japonicus, which contained triterpene glycosides called holotoxins. The holotoxins worked as a fungicide, and their minimum inhibitory concentrations for Candida albicans were 7 µg/mL. Eight individuals in the nursing home took the sea cucumber jelly for a week and their oral Candida were counted before and after the intervention. Nine individuals took a control jelly without S. japonicus. The sea cucumber jelly showed inhibitory effects on the oral Candida. Thus, daily consumption of the S. japonicus jelly has the potential to reduce the oral Candida load in the elderly in nursing homes.
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Keywords:
Stichopus japonicus; holotoxin; Candida; oral care; elderly in nursing home
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MDPI and ACS Style
Yano, A.; Abe, A.; Aizawa, F.; Yamada, H.; Minami, K.; Matsui, M.; Kishi, M. The Effect of Eating Sea Cucumber Jelly on Candida Load in the Oral Cavity of Elderly Individuals in a Nursing Home. Mar. Drugs 2013, 11, 4993-5007.
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