Review Reports

Round 1

Reviewer 1 Report

An interesting paper on an important topic. A suggest several changes:

1. The abstract should be more detailed, please at least mention the current treatment options that you review in the paper

2. The paper is well-organized, however, it is lacking some kind of summary/discussion at the end

3. You should include dapsone in your review, it is used in a rare variant of bullous systemic lupus erythematosus

4. What about cyclosporin A? Are there any differences in the safety profile etc when compared to tacrolimus?

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

 Synthetic pharmacotherapy for systemic lupus erythematosus: 2 potential mechanisms of action, efficacy, and safety

Location (pages)	Type of correction / Problem identified	Action needed
39-40	Change in text	Where is written “...desire of children…” should be better meant by “desire of parenthood”
83-90	Change in paragraph	I recommend only one paragraph, since both paragraphs are in the same context. Paragraphs should be linked.
83-99	Substitute Repetead words	The word “Also” is fully used many times to express continuity. Possible suggestions: In addition; Furthermore; In this way; Moreover; Additionally, etc.
103-104	Sentence continuity	The sentence was abruptly cut and discontinuated, author should verify such typos
176-198	Topic comprehension	An introductory paragraph is needed in topic 2.3 Monitoring (such as was done in topic 2.2 as well). Suggestion “As observed in several references as depicted as follows, the criteria of… “
Minor typos in manuscript that should be checked.

Author Response

Please see the attachment

Author Response File: Author Response.pdf