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Medicina, Volume 58, Issue 12

2022 December - 180 articles

Cover Story: Sepsis and septic shock have an enormous burden on our healthcare systems, with more than 30 million people worldwide suffering from these diseases. Emergency providers must be able to immediately recognise the presence of sepsis and its severity to improve the management of this disease. The use of biomarkers could help to promptly identify the disease upon the ED patients’ arrival and stratify the risk of progression to septic shock. This study evaluated the prognostic performance of new POCT biomarkers, bio-adrenomedullin and proenkephalin, in patients with sepsis upon ED arrival. The results show that both biomarkers performed relatively well as predictors of short-term mortality. It seems that, in patients with sepsis, the prompt evaluation of these two biomarkers upon ED arrival could help to optimize physicians’ therapeutical decision-making and final diagnosis. View this paper
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Articles (180)

  • Case Report
  • Open Access
2 Citations
2,684 Views
9 Pages

19 December 2022

Background. Oncogenic osteomalacia (OO), also known as tumor-induced osteomalacia (TIO), is a rare paraneoplastic syndrome caused by mesechymal tumors secreting fibroblast growth factor 23 (FGF23). Common in middle age, these tumors are often disclos...

  • Article
  • Open Access
2 Citations
3,513 Views
21 Pages

19 December 2022

Background: Malignant pleural mesothelioma (MPM) is an aggressive and rare malignant pleural tumor. Methods: MPM patients diagnosed in Beijing Chaoyang Hospital and Beijing Tongren Hospital were the focus of this study. We collected and analyzed the...

  • Case Report
  • Open Access
1 Citations
3,829 Views
7 Pages

Erythema Nodosum following Nocardia Infection: A Case Report

  • Sujing Li,
  • Bingzhou Ji,
  • Yan Teng,
  • Hui Tang,
  • Hong Cui,
  • Xiaohua Tao,
  • Yibin Fan and
  • Youming Huang

19 December 2022

Cutaneous nocardiosis is a rare bacterial infection that can result in various dermatologic manifestations such as actinomycetoma, lymphocutaneous infection, superficial skin infection, and secondary infection due to hematogenous dissemination. We re...

  • Article
  • Open Access
21 Citations
2,775 Views
9 Pages

Association of Uric Acid Albumin Ratio with Recurrence of Atrial Fibrillation after Cryoballoon Catheter Ablation

  • Mehmet Baran Karataş,
  • Gündüz Durmuş,
  • Ahmet Zengin,
  • Murat Gökalp,
  • Mert İlker Hayıroğlu,
  • Tufan Çınar,
  • Kadir Gürkan and
  • Neşe Çam

19 December 2022

Objective: Despite improvements in the technology of catheter ablation of atrial fibrillation (AF), recurrences are still a major problem, even after a successful procedure. The uric acid/albumin ratio (UAR), which is an inexpensive and simple labora...

  • Article
  • Open Access
5 Citations
3,368 Views
8 Pages

Interaction between Dexamethasone, Ropivacaine, and Contrast Media Used in Interventional Pain Treatment: Considerations in Safety

  • Yeon Ju Kim,
  • Yeon-Dong Kim,
  • Hyungtae Kim,
  • Dong Ji Ahn,
  • Ha-Jung Kim,
  • Won Uk Koh and
  • Young-Jin Ro

19 December 2022

Background and Objectives: Although epidural steroid injections are used as an effective treatment, this technique is associated with rare but serious ischemic complications, especially when particulate steroids are used. However, recent studies have...

  • Review
  • Open Access
32 Citations
14,306 Views
14 Pages

A Review of Neovascular Glaucoma: Etiology, Pathogenesis, Diagnosis, and Treatment

  • Danielė Urbonavičiūtė,
  • Dovilė Buteikienė and
  • Ingrida Janulevičienė

18 December 2022

Neovascular glaucoma (NVG) is a rare, aggressive, blinding secondary glaucoma, which is characterized by neovascularization of the anterior segment of the eye and leading to elevation of the intraocular pressure (IOP). The main etiological factor is...

  • Article
  • Open Access
13 Citations
5,398 Views
15 Pages

Urologic Complication after Laparoscopic Hysterectomy in Gynecology Oncology: A Single-Center Analysis and Narrative Review of the Literature

  • Vito Andrea Capozzi,
  • Luciano Monfardini,
  • Elisa Scarpelli,
  • Giuseppe Barresi,
  • Isabella Rotondella,
  • Alessandra De Finis,
  • Davide Scebba,
  • Giuseppe Maglietta,
  • Stefano Cianci and
  • Roberto Berretta
  • + 1 author

18 December 2022

Background and Objectives: Minimally invasive surgery (MIS) has recently increased its application in the treatment of gynecological malignancies. Despite technological and surgical advances, urologic complications (UC) are still the main concern in...

  • Article
  • Open Access
19 Citations
3,746 Views
9 Pages

Predictive Factors for Poor Outcome following Chemonucleolysis with Condoliase in Lumbar Disc Herniation

  • Shu Takeuchi,
  • Junya Hanakita,
  • Toshiyuki Takahashi,
  • Tomoo Inoue,
  • Manabu Minami,
  • Izumi Suda,
  • Sho Nakamura and
  • Ryo Kanematsu

18 December 2022

Background and Objectives: Condoliase, a chondroitin sulfate ABC endolyase, is a novel and minimally invasive chemonucleolytic drug for lumbar disc herniation. Despite the growing number of treatments for lumbar disc herniation, the predicting factor...

  • Systematic Review
  • Open Access
2 Citations
3,380 Views
10 Pages

Meta-Analysis of Survival Effects of Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1)

  • Soo Young Jeong,
  • Kyung-jun Lee,
  • Jieum Cha,
  • So Yoon Park,
  • Hyeong Su Kim,
  • Jung Han Kim,
  • Jae-Jun Lee,
  • Namhyeok Kim and
  • Sung Taek Park

17 December 2022

Background and Objectives: Identification and targeting of membrane proteins in tumor cells is one of the key steps in the development of cancer drugs. The receptor tyrosine kinase-like orphan receptor (ROR) type 1 is a type-I transmembrane protein e...

  • Article
  • Open Access
27 Citations
4,150 Views
11 Pages

Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot

  • Sanja Vujčić,
  • Jelena Kotur-Stevuljević,
  • Jelena Vekić,
  • Iva Perović-Blagojević,
  • Tatjana Stefanović,
  • Sanja Ilić-Mijailović,
  • Branka Koprivica Uzelac,
  • Srećko Bosić,
  • Tamara Antonić and
  • Manfredi Rizzo
  • + 3 authors

17 December 2022

Background and Objectives: Diabetic foot (DF) development is driven by complex interactions of hyperglycemia, inflammation, and oxidative stress (OS). We aimed to investigate OS and inflammatory biomarkers in patients with DF and their potential to i...

  • Review
  • Open Access
2 Citations
2,727 Views
12 Pages

Developing Cardiothoracic Surgical Critical Care Intensivists: A Case for Distinct Training

  • Rafal Kopanczyk,
  • Micah T. Long,
  • Sree V. Satyapriya,
  • Amar M. Bhatt and
  • Michael Lyaker

17 December 2022

Cardiothoracic surgical critical care medicine is practiced by a diverse group of physicians including surgeons, anesthesiologists, pulmonologists, and cardiologists. With a wide array of specialties involved, the training of cardiothoracic surgical...

  • Case Report
  • Open Access
6 Citations
3,327 Views
6 Pages

17 December 2022

Primary squamous cell carcinoma (SCC) of the liver is a rare disease that is difficult to diagnose until the pathology is confirmed. The age of the patients generally ranges from 18 to 83 years. The pathogenesis of primary SCC of the liver remains un...

  • Article
  • Open Access
21 Citations
7,048 Views
11 Pages

Efficacy Comparison between Kegel Exercises and Extracorporeal Magnetic Innervation in Treatment of Female Stress Urinary Incontinence: A Randomized Clinical Trial

  • Mislav Mikuš,
  • Držislav Kalafatić,
  • Adam Vrbanić,
  • Marina Šprem Goldštajn,
  • Mislav Herman,
  • Marta Živković Njavro,
  • Klara Živković,
  • Goran Marić and
  • Mario Ćorić

17 December 2022

Background and Objectives: To estimate the effectiveness of Kegel exercises versus extracorporeal magnetic innervation (EMI) in the treatment of stress urinary incontinence (SUI). Materials and Methods: A parallel group, randomized clinical trial was...

  • Article
  • Open Access
8 Citations
7,654 Views
11 Pages

16 December 2022

Background and objective: Fever is a common symptom in patients with traumatic brain injury (TBI). However, the effect of fever on the clinical outcomes of patients with TBI is not well characterized. Our study aims to determine the impact of fever o...

  • Article
  • Open Access
13 Citations
2,720 Views
13 Pages

Impact of the COVID-19 Pandemic on Diagnosis and Management of Gynecological Cancer: A Single-Center Analysis

  • Dora Antunes,
  • Lisandra Mendonça,
  • Ângela Melo,
  • Sónia Gonçalves,
  • Francisco Nogueira Martins and
  • Nuno Nogueira Martins

16 December 2022

Background and Objectives: The COVID-19 pandemic impacted health systems worldwide, particularly cancer care. Because the actual implications of these changes on gynecological oncology healthcare are still unclear, we aim to evaluate the impact of th...

  • Article
  • Open Access
14 Citations
3,106 Views
9 Pages

Relationship between Fasting Times and Emergence Delirium in Children Undergoing Magnetic Resonance Imaging under Sedation

  • Ayşe Neslihan Balkaya,
  • Canan Yılmaz,
  • Çağdaş Baytar,
  • Asiye Demirel,
  • Nermin Kılıçarslan,
  • Filiz Ata,
  • Nurcan Kat Kaçmaz and
  • Mehmet Gamlı

16 December 2022

Background and Objectives: This study aimed to determine whether there is a relationship between preoperative fasting time, fasting blood glucose (FBG), and postoperative emergence delirium (ED) in pediatric patients undergoing MRI under sedation. Ma...

  • Article
  • Open Access
7 Citations
5,446 Views
13 Pages

Predictive Factors for the Prognosis of Alcoholic Liver Cirrhosis

  • Anca Trifan,
  • Horia Minea,
  • Adrian Rotaru,
  • Carol Stanciu,
  • Remus Stafie,
  • Ermina Stratina,
  • Sebastian Zenovia,
  • Robert Nastasa,
  • Ana-Maria Singeap and
  • Camelia Cojocariu
  • + 6 authors

16 December 2022

Alcoholic liver cirrhosis (ALC) is a disease with multiple complications and is associated with poor prognosis and significant mortality. Identifying risk factors associated with a poor outcome is important to ensure effective treatment and increase...

  • Review
  • Open Access
14 Citations
10,191 Views
18 Pages

Characteristics and Future Direction of Tibialis Posterior Tendinopathy Research: A Scoping Review

  • Hye Chang Rhim,
  • Ravi Dhawan,
  • Ashley E. Gureck,
  • Daniel E. Lieberman,
  • David C. Nolan,
  • Ramy Elshafey and
  • Adam S. Tenforde

16 December 2022

Background and Objectives: Tibialis posterior tendon pathologies have been traditionally categorized into different stages of posterior tibial tendon dysfunction (PTTD), or adult acquired flatfoot deformity (AAFD), and more recently to progressive co...

  • Case Report
  • Open Access
2 Citations
2,780 Views
6 Pages

Large Intrathoracic Desmoid Tumor and Re-Expansion Pulmonary Edema: Case Report and Review of the Literature

  • Efstathia Pistioli,
  • Eleftheria Soulioti,
  • Emmanouil I. Kapetanakis,
  • Thrasyvoulos P. Michos,
  • Periklis I. Tomos and
  • Tatiana Sidiropoulou

16 December 2022

Re-expansion pulmonary edema is a potentially life-threatening situation following thoracic surgery of a compromised lung. We report the case of a 24-year-old female scheduled for a resection of a large intrathoracic desmoid tumor that presented with...

  • Article
  • Open Access
1 Citations
2,432 Views
13 Pages

Assessment of Characteristics of Imaging Biomarkers for Quantifying Anterior Cingulate Cortex Changes: A Twin Study of Middle- to Advanced-Aged Populations in East Asia

  • Hiroto Takahashi,
  • Yoshiyuki Watanabe,
  • Tomoki Hirakawa,
  • Hisashi Tanaka,
  • Noriyuki Tomiyama,
  • Yuta Koto,
  • Norio Sakai and
  • Osaka Twin Research Group

16 December 2022

Background and Objectives: Our aim was to assess genetic and environmental effects on surface morphological parameters for quantifying anterior cingulate cortex (ACC) changes in middle- to advanced-age East Asians using twin analysis. Materials and M...

  • Brief Report
  • Open Access
5 Citations
5,191 Views
9 Pages

16 December 2022

Cardiothoracic surgical intensive care has developed in response to advances in cardiothoracic surgery. The invention of the cardiopulmonary bypass machine facilitated a motionless and bloodless surgical field and made operations of increasing comple...

  • Article
  • Open Access
12 Citations
4,013 Views
11 Pages

Management of Complex Acetabular Fractures by Using 3D Printed Models

  • Stoyan Ivanov,
  • Petar Valchanov,
  • Stoyan Hristov,
  • Deyan Veselinov and
  • Boyko Gueorguiev

15 December 2022

Background and Objectives: Using 3D printed models in orthopaedics and traumatology contributes to a better understanding of injury patterns regarding surgical approaches, reduction techniques, and fracture fixation methods. The aim of this study is...

  • Article
  • Open Access
11 Citations
11,245 Views
12 Pages

15 December 2022

Background and Objectives: To achieve pregnancy, it is highly beneficial to identify the time of ovulation as well as the greater period of fertile days during which sperm may survive leading up to ovulation. Confirming successful ovulation is also c...

  • Article
  • Open Access
7 Citations
2,631 Views
13 Pages

Utility of Measuring Circulating Bio-Adrenomedullin and Proenkephalin for 30-Day Mortality Risk Prediction in Patients with COVID-19 and Non-COVID-19 Interstitial Pneumonia in the Emergency Department

  • Ilaria Dafne Papasidero,
  • Gabriele Valli,
  • Dario Marin,
  • Alberto Del Sasso,
  • Antonio De Magistris,
  • Elisa Cennamo,
  • Silvia Casalboni,
  • Francesca De Marco,
  • Roberta Rocchi and
  • Salvatore Di Somma
  • + 6 authors

15 December 2022

Background and Objectives: In order to accelerate the risk stratification of patients referred to the Emergency Department (ED) with interstitial pneumonia, it could be useful to provide new and effective laboratory tests for use. The aim of our stud...

  • Article
  • Open Access
8 Citations
4,714 Views
14 Pages

Safety and Efficacy of the Transaxillary Access for Minimally Invasive Mitral Valve Surgery—A Propensity Matched Competitive Analysis

  • Ali Taghizadeh-Waghefi,
  • Sebastian Arzt,
  • Veronica De Angelis,
  • Jana Schiffarth,
  • Asen Petrov,
  • Matuš Tomko,
  • Konstantin Alexiou,
  • Klaus Matschke,
  • Utz Kappert and
  • Manuel Wilbring

15 December 2022

Background and Objectives: Transaxillary access is a straightforward “single incision—direct vision” concept, based on a 5 cm skin incision in the right anterior axillary line. It is suitable for aortic, mitral and tricuspid surgery...

  • Article
  • Open Access
10 Citations
3,250 Views
10 Pages

15 December 2022

Background and Objectives: Real-world evidence should reflect the evidence obtained from controlled trials; therefore, the study aimed to compare biosimilar adalimumab (bADA) to original adalimumab (oADA) in terms of efficacy and safety in a real-lif...

  • Article
  • Open Access
2,554 Views
9 Pages

Routine Detachment of the Anterior and Septal Tricuspid Leaflets Simplifies VSD Closure and Improves the Outcomes

  • Rodrigo Sandoval Boburg,
  • Christian Schlensak,
  • Michael Hofbeck,
  • Harry Magunia,
  • Rafal Berger,
  • Walter Jost and
  • Migdat Mustafi

15 December 2022

Background and Objectives: The closure of perimembranous ventricular septal defects (VSDs) is one of the most common surgeries performed in infancy. The technique of detachment of the anterior and septal leaflets of the tricuspid valve (TV) with subs...

  • Review
  • Open Access
10 Citations
4,713 Views
14 Pages

Drug-Induced Liver Injury in Hospitalized Patients during SARS-CoV-2 Infection

  • Eleni Karlafti,
  • Daniel Paramythiotis,
  • Konstantina Pantazi,
  • Vasiliki Epameinondas Georgakopoulou,
  • Georgia Kaiafa,
  • Petros Papalexis,
  • Adonis A. Protopapas,
  • Eleftheria Ztriva,
  • Varvara Fyntanidou and
  • Christos Savopoulos

15 December 2022

In the last few years, the world has had to face the SARS-CoV-2 infection and its multiple effects. Even though COVID-19 was first considered to be a respiratory disease, it has an extended clinical spectrum with symptoms occurring in many tissues, a...

  • Article
  • Open Access
4 Citations
2,800 Views
10 Pages

Development and Validation of a Difficulty Scoring System for Laparoscopic Liver Resection to Treat Hepatolithiasis

  • Yeongsoo Jo,
  • Jai Young Cho,
  • Ho-Seong Han,
  • Yoo-Seok Yoon,
  • Hae Won Lee,
  • Jun Suh Lee,
  • Boram Lee,
  • Eunhye Lee,
  • Yeshong Park and
  • Junghyun Lee
  • + 1 author

15 December 2022

Background and Objectives: A difficulty scoring system was previously developed to assess the difficulty of laparoscopic liver resection (LLR) for liver tumors; however, we need another system for hepatolithiasis. Therefore, we developed a novel diff...

  • Article
  • Open Access
2 Citations
3,618 Views
11 Pages

Hospitalization Duration for Acute Myocardial Infarction: A Temporal Analysis of 18-Year United States Data

  • Anusha G. Bhat,
  • Mandeep Singh,
  • Sri Harsha Patlolla,
  • Peter Matthew Belford,
  • David X. Zhao and
  • Saraschandra Vallabhajosyula

15 December 2022

Background and objectives: Primary percutaneous coronary intervention (PCI)-related outcomes in acute myocardial infarction (AMI) have improved over time, but there are limited data on the length of stay (LOS) in relation to in-hospital mortality. Ma...

  • Case Report
  • Open Access
3 Citations
2,715 Views
5 Pages

Case Report of Dermoscopic Aspects and Reflectance Confocal Microscopy Description of Segmental Leiomyoma and Relative Management

  • Giovanni Paolino,
  • Riccardo Pampena,
  • Nathalie Rizzo,
  • Matteo Riccardo Di Nicola and
  • Santo Raffaele Mercuri

15 December 2022

Cutaneous leiomyoma is a benign tumor, mainly composed of smooth muscle cells and arising from the arrector pili muscle of hair follicles. The diagnosis of leiomyomas is of paramount importance, as they can often be associated with underlying maligna...

  • Case Report
  • Open Access
1 Citations
2,396 Views
10 Pages

Monoamine Oxidase (MAO) Is Expressed at the Level of Mitral Valve with Severe Regurgitation in Hypertrophic Obstructive Cardiomyopathy: A Case Report

  • Ana Lascu,
  • Raluca Șoșdean,
  • Loredana Nicoleta Ionică,
  • Alexandru S. Pescariu,
  • Lucian Petrescu,
  • Adina Ionac,
  • Constantin T. Luca,
  • Adrian Sturza and
  • Horea B. Feier

15 December 2022

Hypertrophic obstructive cardiomyopathy (HOCM) is one of the most common hereditary heart diseases. The severely hypertrophied interventricular septum combined with the systolic anterior movement (SAM) of the mitral valve (MV) frequently cause a sign...

  • Article
  • Open Access
3 Citations
2,171 Views
11 Pages

15 December 2022

Background and Objectives: Previous studies have suggested that long-term β-blocker therapy before sepsis is associated with reduced mortality. Sepsis-associated coagulopathy (SAC) remains a common complication in patients with sepsis and is ass...

  • Article
  • Open Access
1 Citations
2,740 Views
18 Pages

Platelet-Rich Plasma for Pleurodesis: An Experimental Study in Rabbits

  • Styliani Maria Kolokotroni,
  • Dimitrios Lamprinos,
  • Nikolaos Goutas,
  • Emmanouil I. Kapetanakis,
  • Konstantinos Kontzoglou,
  • Despoina Perrea and
  • Periklis Tomos

15 December 2022

Background and Objectives: This study was designed to evaluate platelet-rich plasma (PRP) as a method of pleurodesis in a rabbit model. Pleurodesis with PRP was compared against the gold-standard use of talc. The secondary evaluation assessed the ide...

  • Article
  • Open Access
7 Citations
3,322 Views
12 Pages

Identification of Genomic Variants of SARS-CoV-2 Using Nanopore Sequencing

  • Ionut Dragos Capraru,
  • Mirabela Romanescu,
  • Flavia Medana Anghel,
  • Cristian Oancea,
  • Catalin Marian,
  • Ioan Ovidiu Sirbu,
  • Aimee Rodica Chis and
  • Paula Diana Ciordas

15 December 2022

Background and Objectives: SARS-CoV-2 is the first global threat and life-changing event of the twenty-first century. Although efficient treatments and vaccines have been developed, due to the virus’s ability to mutate in key regions of the gen...

  • Article
  • Open Access
7 Citations
2,576 Views
9 Pages

15 December 2022

Background and Objectives: Benign osseous tumors of the spinal column comprise about 10% of all spinal tumors and are rare cause for surgery. However, these tumors pose various management challenges and conventional surgery may be associated with sig...

  • Article
  • Open Access
2 Citations
2,128 Views
10 Pages

Clinical, Radiographic, and Inflammatory Peri-Implant Parameters around Narrow Diameter Implant Crowns among Prediabetic and Non-Diabetic Subjects

  • Abdulaziz Alsahhaf,
  • Yasser Alali,
  • Sultan Albeshri,
  • Abdulaziz K. A. Subayt,
  • Abdullah Alomayri,
  • Tariq Abduljabbar and
  • Fahim Vohra

14 December 2022

Background and Objectives: To compare the clinical, radiographic, and inflammatory peri-implant parameters around narrow diameter implants (NDI) supported single and splinted crowns in non-diabetics and prediabetes. Materials and Methods: The clinica...

  • Case Report
  • Open Access
2 Citations
3,236 Views
8 Pages

Papillary Squamotransitional Cell Carcinoma of the Uterine Cervix with Atypical Presentation: A Case Report with a Literature Review

  • Angel Yordanov,
  • Milen Karaivanov,
  • Stoyan Kostov,
  • Yavor Kornovski,
  • Yonka Ivanova,
  • Stanislav Slavchev,
  • Venelina Todorova and
  • Mariela Vasileva-Slaveva

14 December 2022

Introduction: Cervical cancer is the fourth most prevalent malignancy and the fourth leading cause of cancer-related death in women around the world. Histologically, squamous cell carcinoma (SCC) is the most common form of cervical cancer. SCC has se...

  • Case Report
  • Open Access
2 Citations
3,543 Views
9 Pages

Granulomatosis with Polyangiitis (GPA)—A Multidisciplinary Approach of a Case Report

  • Cornelia M. Trandafir,
  • Nicolae Constantin Balica,
  • Delia I. Horhat,
  • Ion C. Mot,
  • Cristian A. Sarau and
  • Marioara Poenaru

13 December 2022

Granulomatosis with polyangiitis is an atypical, multisystem disease with unknown etiology that generally affects both genders equally, with a predominance in the Caucasian racial group for individuals in their fourth decade. The disease affects the...

  • Article
  • Open Access
9 Citations
2,472 Views
10 Pages

Albumin-Bilirubin Grade as a Novel Predictor of the Development and Short-Term Survival of Post-Banding Ulcer Bleeding Following Endoscopic Variceal Ligation in Cirrhotic Patients

  • Chun-Wei Chen,
  • Chia-Jung Kuo,
  • Chao-Wei Lee,
  • Tony Kuo,
  • Cheng-Tang Chiu,
  • Chun-Jung Lin,
  • Siew-Na Lim,
  • Chau-Ting Yeh and
  • Wey-Ran Lin

13 December 2022

Background and Objectives: Endoscopic variceal ligation (EVL) is the primary and secondary treatment for acute esophageal variceal bleeding. Post-banding ulcer bleeding (PBUB) may lead to bleeding episodes following EVL, increasing mortality. The aim...

  • Article
  • Open Access
1 Citations
1,882 Views
9 Pages

Practical Relevance of Institutional Guidelines in Translational Large Animal Studies of Cartilage Repair—A Multidisciplinary Survey

  • Moritz Riedl,
  • Markus Rupp,
  • Nike Walter,
  • Leopold Henssler,
  • Maximilian Kerschbaum,
  • Daniel Popp,
  • Gianluca Vadalà,
  • Volker Alt,
  • Denitsa Docheva and
  • Christian G. Pfeifer

13 December 2022

Background and Objective: Translational large animal models are inevitable to transfer cartilage repair methods into clinical practice. Guidelines for these trials have been published by guiding agencies (FDA, ASTM, EMEA) including recommendations fo...

  • Systematic Review
  • Open Access
15 Citations
4,048 Views
15 Pages

Concomitant Guillain–Barré Syndrome and COVID-19: A Meta-Analysis of Cases

  • Skylar A. Bentley,
  • Sarfraz Ahmad,
  • Firas H. Kobeissy and
  • Hale Z. Toklu

13 December 2022

Background and Objectives: Recent findings demonstrate that the transmigration of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) to the nervous system implicates severe neurotropic pathologies, including the onset of the rare disease ca...

  • Case Report
  • Open Access
5 Citations
4,122 Views
5 Pages

12 December 2022

Orbitocranial penetrating injuries (OPIs) caused by wooden foreign bodies (WFBs) are very rare and life threatening. Their diagnosis and treatment could be challenging for an ophthalmologist, requiring us to remain alert for possible intracranial ext...

  • Article
  • Open Access
6 Citations
3,926 Views
8 Pages

Kawasaki Disease with Hepatobiliary Manifestations

  • Siti Aisyah Suhaini,
  • Abdullah Harith Azidin,
  • Chooi San Cheah,
  • Wendy Lee Wei Li,
  • Mohammad Shukri Khoo,
  • Noor Akmal Shareela Ismail and
  • Adli Ali

12 December 2022

Background and Objectives: Kawasaki Disease (KD) incidence has been on the rise globally throughout the years, particularly in the Asia Pacific region. KD can be diagnosed based on several clinical criteria. Due to its systemic inflammatory nature, m...

  • Article
  • Open Access
2 Citations
2,808 Views
14 Pages

Clinical Phenotypes of Dual Kidney Transplant Recipients in the United States as Identified through Machine Learning Consensus Clustering

  • Supawit Tangpanithandee,
  • Charat Thongprayoon,
  • Caroline C. Jadlowiec,
  • Shennen A. Mao,
  • Michael A. Mao,
  • Pradeep Vaitla,
  • Napat Leeaphorn,
  • Wisit Kaewput,
  • Pattharawin Pattharanitima and
  • Wisit Cheungpasitporn
  • + 3 authors

12 December 2022

Background and Objectives: Our study aimed to cluster dual kidney transplant recipients using an unsupervised machine learning approach to characterize donors and recipients better and to compare the survival outcomes across these various clusters. M...

  • Case Report
  • Open Access
3 Citations
2,809 Views
9 Pages

Intestinal Mucosa-Associated Lymphoid Tissue Lymphoma Transforming into Diffuse Large B-Cell Lymphoma in a Young Adult Patient with Neurofibromatosis Type 1: A Case Report

  • Hideki Kosako,
  • Yusuke Yamashita,
  • Ken Tanaka,
  • Hiroyuki Mishima,
  • Ryuta Iwamoto,
  • Akira Kinoshita,
  • Shin-ichi Murata,
  • Koichi Ohshima,
  • Koh-ichiro Yoshiura and
  • Shinobu Tamura
  • + 1 author

12 December 2022

Background: Neurofibromatosis type 1 (NF1) is a hereditary cancer syndrome characterized by multiple café-au-lait macules on the skin. Lymphoproliferative malignancies associated with NF1 are limited, although the most common are brain tumors....

  • Article
  • Open Access
7 Citations
3,671 Views
13 Pages

Gene Expression Profiling of Peripheral Blood Mononuclear Cells in Type 2 Diabetes: An Exploratory Study

  • Hana M. A. Fakhoury,
  • Muhammad Affan Elahi,
  • Saud Al Sarheed,
  • Mohammed Al Dubayee,
  • Awad Alshahrani,
  • Mahmoud Zhra,
  • Arwa Almassri and
  • Ahmad Aljada

12 December 2022

Background and Objectives: Visceral obesity is associated with chronic low-grade inflammation that predisposes to metabolic syndrome. Indeed, infiltration of adipose tissue with immune–inflammatory cells, including ‘classical’ infla...

  • Case Report
  • Open Access
4 Citations
3,106 Views
8 Pages

HOT CRT—The Effective Combination of Conventional Cardiac Resynchronization and His Bundle Pacing

  • Peter-Stephan Wolff,
  • Anna Winnicka,
  • Adam Ciesielski,
  • Malte Unkell,
  • Grzegorz Zawadzki,
  • Agnieszka Sławuta and
  • Jacek Gajek

12 December 2022

Background and Objectives: Cardiac Resynchronization Therapy (CRT) has, besides its benefits, various limitations. For instance, atrial fibrillation (AF) has a huge impact on the therapy efficacy. It usually reduces the overall BiV pacing percentage...

  • Review
  • Open Access
4 Citations
3,340 Views
21 Pages

State-of-the-Art and Future Directions in Organ Regeneration with Mesenchymal Stem Cells and Derived Products during Dynamic Liver Preservation

  • Nicola De Stefano,
  • Alberto Calleri,
  • Victor Navarro-Tableros,
  • Federica Rigo,
  • Damiano Patrono and
  • Renato Romagnoli

12 December 2022

Transplantation is currently the treatment of choice for end-stage liver diseases but is burdened by the shortage of donor organs. Livers from so-called extended-criteria donors represent a valid option to overcome organ shortage, but they are at ris...

  • Case Report
  • Open Access
1 Citations
2,787 Views
7 Pages

12 December 2022

Management of early-stage cervical cancer (CC) in young women often faces challenges to preserve fertility, as well as to achieve an adequate oncological outcome. Although existing evidence supports a fertility-sparing treatment in the case of tumors...

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Medicina - ISSN 1648-9144