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Article

Quantitative Assessment of Liver Impairment in Chronic Viral Hepatitis with [99mTc]Tc-Mebrofenin: A Noninvasive Attempt to Stage Viral Hepatitis-Associated Liver Fibrosis

1
Faculty of Medicine, Vilnius University, LT-03101 Vilnius, Lithuania
2
Department of Radiology, Medical Academy, Lithuanian University of Health Science Kauno Klinikos, LT-50161 Kaunas, Lithuania
3
National Center of Pathology, LT-03101 Vilnius, Lithuania
4
Centre of Hepatology, Gastroenterology and Dietology, Vilnius University Hospital Santaros Klinikos, LT-08661 Vilnius, Lithuania
*
Author to whom correspondence should be addressed.
Academic Editor: Hirayuki Enomoto
Medicina 2022, 58(10), 1333; https://doi.org/10.3390/medicina58101333
Received: 28 June 2022 / Revised: 14 September 2022 / Accepted: 16 September 2022 / Published: 23 September 2022
(This article belongs to the Topic Liver Fibrosis and Cirrhosis)
Background and objectives—Chronic viral hepatitis B and C infections are one of the leading causes of chronic liver impairment, resulting in liver fibrosis and liver cirrhosis. An early diagnosis with accurate liver fibrosis staging leads to a proper diagnosis, thus tailoring correct treatment. Both invasive and noninvasive techniques are used in the diagnosis and staging of chronic liver impairment. Those techniques include liver biopsy, multiple serological markers (as either single tests or combined panels), and imaging examinations, such as ultrasound or magnetic resonance elastography. Nuclear medicine probes may also be employed in staging liver fibrosis, although the literature scarcely reports this. The purpose of our study was to investigate whether a dynamic liver scintigraphy with [99mTc]Tc-mebrofenin has any value in staging or grading chronic liver damage. Materials and Methods—We prospectively enrolled patients with chronic viral hepatitis B and C infection referred for liver biopsy. All patient underwent dynamic liver scintigraphy with 99mTc-mebrofenin prior to liver biopsy. Dynamic liver scintigraphy was performed immediately after intravenous tracer injection for 30 min scanning time. Multiple scintigraphy parameters were calculated (whole liver lobe and focal area time to peak (TTP), 30 min to peak ratio (30/peak), whole lobe and focal area slope index in 350 s (slope_350). Liver biopsy took place shortly after imaging. Results—We found that many dynamic scintigraphic parameters are positively or negatively associated with different stages of liver fibrosis. The main parameters that showed most value are the ratio between 30 min and the peak of the dynamic curve (30/peak_dex (ratio)), and liver clearance corrected for body surface area and liver area (LCL_m2_dm2 (%/min/m2/dm2)). Conclusions—Our present study proves that conducting dynamic liver scintigraphies with [99mTc]Tc-mebrofenin has potential value in staging liver fibrosis. The benefits of this method, including whole liver imaging and direct imaging of the liver function, provide an advantage over presently used quantitative imaging modalities. View Full-Text
Keywords: liver fibrosis; chronic liver disease; hepatobiliary scintigraphy; 99mTc-mebrofenin liver fibrosis; chronic liver disease; hepatobiliary scintigraphy; 99mTc-mebrofenin
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MDPI and ACS Style

Jocius, D.; Vajauskas, D.; Mikelis, K.; Jokubauskiene, S.; Jakutiene, J.; Strupas, K.; Tamosiunas, A.E. Quantitative Assessment of Liver Impairment in Chronic Viral Hepatitis with [99mTc]Tc-Mebrofenin: A Noninvasive Attempt to Stage Viral Hepatitis-Associated Liver Fibrosis. Medicina 2022, 58, 1333. https://doi.org/10.3390/medicina58101333

AMA Style

Jocius D, Vajauskas D, Mikelis K, Jokubauskiene S, Jakutiene J, Strupas K, Tamosiunas AE. Quantitative Assessment of Liver Impairment in Chronic Viral Hepatitis with [99mTc]Tc-Mebrofenin: A Noninvasive Attempt to Stage Viral Hepatitis-Associated Liver Fibrosis. Medicina. 2022; 58(10):1333. https://doi.org/10.3390/medicina58101333

Chicago/Turabian Style

Jocius, Donatas, Donatas Vajauskas, Kipras Mikelis, Skirmante Jokubauskiene, Jolita Jakutiene, Kestutis Strupas, and Algirdas E. Tamosiunas. 2022. "Quantitative Assessment of Liver Impairment in Chronic Viral Hepatitis with [99mTc]Tc-Mebrofenin: A Noninvasive Attempt to Stage Viral Hepatitis-Associated Liver Fibrosis" Medicina 58, no. 10: 1333. https://doi.org/10.3390/medicina58101333

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