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Volume 46
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Review

Role of Nutrients Regulating Myeloid Derived Suppressor Cells in Cancer: A Scoping Review

by
Beatriz Pérez-Peláez
1,†,
Carlos Jiménez-Cortegana
1,†,
Luis de la Cruz-Merino
2,3 and
Víctor Sánchez-Margalet
2,3,*
1
Department of Medical Biochemistry and Molecular Biology and Immunology, School of Medicine, Clinical Biochemistry Service, Virgen Macarena University Hospital, University of Seville, 41009 Seville, Spain
2
Department of Medicine, School of Medicine, Clinical Oncology Service, Virgen Macarena University Hospital, University of Seville, 41009 Seville, Spain
3
Institute of Biomedicine of Seville, Virgen Macarena University Hospital, CSIC, University of Seville, 41013 Seville, Spain
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Curr. Issues Mol. Biol. 2024, 46(9), 9286-9297; https://doi.org/10.3390/cimb46090549
Submission received: 2 August 2024 / Revised: 19 August 2024 / Accepted: 21 August 2024 / Published: 23 August 2024
(This article belongs to the Special Issue The Protection and Toxic Reactions of Dietary Supplements: Focusing on Molecular Mechanisms and Treatment)
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Abstract

Myeloid-derived suppressor cells (MDSCs) are immature cells with an immunosuppressive function. MDSCs have been related to inflammation in many settings, including infections, transplantation, obesity, aging, or cancer. In oncological settings, MDSCs participate in tumor immunoescape, growth, and metastasis. Certain nutrients can modify chronic inflammation by their interaction with MDSCs. Therefore, the possible influence of certain nutrients on immune surveillance by their actions on MDSCs and how this may affect the prognosis of cancer patients were evaluated in this scoping review. We identified seven papers, six of which were murine model studies and only one was a human clinical trial. Globally, a significant reduction in cancer growth and progression was observed after achieving a reduction in both MDSCs and their immunosuppressive ability with nutrients such as selected vegetables, icaritin, retinoic acid, curdlan, active vitamin D, soy isoflavones, and green tea. In conclusion, the consumption of certain nutrients may have effects on MDSCs, with beneficial results not only in the prevention of tumor development and growth but also in improving patients’ response.
Keywords: myeloid-derived suppressor cells; nutrients; vitamins; dietary supplements; neoplasms; cancer myeloid-derived suppressor cells; nutrients; vitamins; dietary supplements; neoplasms; cancer

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MDPI and ACS Style

Pérez-Peláez, B.; Jiménez-Cortegana, C.; de la Cruz-Merino, L.; Sánchez-Margalet, V. Role of Nutrients Regulating Myeloid Derived Suppressor Cells in Cancer: A Scoping Review. Curr. Issues Mol. Biol. 2024, 46, 9286-9297. https://doi.org/10.3390/cimb46090549

AMA Style

Pérez-Peláez B, Jiménez-Cortegana C, de la Cruz-Merino L, Sánchez-Margalet V. Role of Nutrients Regulating Myeloid Derived Suppressor Cells in Cancer: A Scoping Review. Current Issues in Molecular Biology. 2024; 46(9):9286-9297. https://doi.org/10.3390/cimb46090549

Chicago/Turabian Style

Pérez-Peláez, Beatriz, Carlos Jiménez-Cortegana, Luis de la Cruz-Merino, and Víctor Sánchez-Margalet. 2024. "Role of Nutrients Regulating Myeloid Derived Suppressor Cells in Cancer: A Scoping Review" Current Issues in Molecular Biology 46, no. 9: 9286-9297. https://doi.org/10.3390/cimb46090549

APA Style

Pérez-Peláez, B., Jiménez-Cortegana, C., de la Cruz-Merino, L., & Sánchez-Margalet, V. (2024). Role of Nutrients Regulating Myeloid Derived Suppressor Cells in Cancer: A Scoping Review. Current Issues in Molecular Biology, 46(9), 9286-9297. https://doi.org/10.3390/cimb46090549

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