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Pharmaceuticals
Volume 17
Issue 5
10.3390/ph17050545
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Article

Antibacterial, Anti-Biofilm, and Anti-Inflammatory Properties of Gelatin–Chitosan–Moringa-Biopolymer-Based Wound Dressings towards Staphylococcus aureus and Escherichia coli

by
Salma Bessalah
1,
Asim Faraz
2,
Mohamed Dbara
1,
Touhami Khorcheni
1,
Mohamed Hammadi
1,
Daniel Jesuwenu Ajose
3 and
Shamsaldeen Ibrahim Saeed
4,5,6,*
1
Livestock and Wildlife Laboratory, Arid Lands Institute (I.R.A.), University of Gabès, Médenine 4119, Tunisia
2
Department of Livestock and Poultry Production, Bahauddin Zakariya University, Multan 60800, Pakistan
3
Department of Microbiology, North-West University, Mmabatho 2735, South Africa
4
Department of Microbiology, Faculty of Veterinary Science, University of Nyala, Nyala P.O. Box 155, Sudan
5
College of Veterinary Medicine, University of Juba, Central Equatoria, Juba P.O. Box 82, South Sudan
6
Nanotechnology Research Group Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Kota Bharu 16100, Malaysia
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2024, 17(5), 545; https://doi.org/10.3390/ph17050545
Submission received: 13 February 2024 / Revised: 29 March 2024 / Accepted: 8 April 2024 / Published: 23 April 2024
(This article belongs to the Special Issue Bioactive Substances and Skin Health: The Role of Pharmacy and Nutrition—Properties and Technology)
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Abstract

In contemporary times, the sustained aspiration of bioengineering and biomedical applications is the progressive advancement of materials characterized by biocompatibility and biodegradability. The investigation of the potential applications of polymers as natural and non-hazardous materials has placed significant emphasis on their physicochemical properties. Thus, this study was designed to investigate the potential of gelatin–chitosan–moringa leaf extract (G–CH–M) as a novel biomaterial for biomedical applications. The wound-dressing G–CH–M biopolymer was synthesized and characterized. The blood haemolysis, anti-inflammatory, antioxidant, and antibacterial activities of the biopolymer were investigated against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacterial isolates. Our results showed that S. aureus swarming motility was drastically affected. However, the biopolymer had no significant effect on the swarming motility of E. coli. In addition, the biopolymer showed high antibacterial capacities, especially against S. aureus. Plasmid DNA was observed to be effectively protected from oxidative stresses by the biopolymer. Furthermore, the biopolymer exhibited greatly suppressed haemolysis (lower than 2%), notwithstanding the elevated concentration of 50 mg/mL. These results indicated that this novel biopolymer formulation could be further developed for wound care and contamination prevention.
Keywords: alternative therapy; biomedical; biopolymers; botanical; natural product; pathogen alternative therapy; biomedical; biopolymers; botanical; natural product; pathogen

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MDPI and ACS Style

Bessalah, S.; Faraz, A.; Dbara, M.; Khorcheni, T.; Hammadi, M.; Ajose, D.J.; Saeed, S.I. Antibacterial, Anti-Biofilm, and Anti-Inflammatory Properties of Gelatin–Chitosan–Moringa-Biopolymer-Based Wound Dressings towards Staphylococcus aureus and Escherichia coli. Pharmaceuticals 2024, 17, 545. https://doi.org/10.3390/ph17050545

AMA Style

Bessalah S, Faraz A, Dbara M, Khorcheni T, Hammadi M, Ajose DJ, Saeed SI. Antibacterial, Anti-Biofilm, and Anti-Inflammatory Properties of Gelatin–Chitosan–Moringa-Biopolymer-Based Wound Dressings towards Staphylococcus aureus and Escherichia coli. Pharmaceuticals. 2024; 17(5):545. https://doi.org/10.3390/ph17050545

Chicago/Turabian Style

Bessalah, Salma, Asim Faraz, Mohamed Dbara, Touhami Khorcheni, Mohamed Hammadi, Daniel Jesuwenu Ajose, and Shamsaldeen Ibrahim Saeed. 2024. "Antibacterial, Anti-Biofilm, and Anti-Inflammatory Properties of Gelatin–Chitosan–Moringa-Biopolymer-Based Wound Dressings towards Staphylococcus aureus and Escherichia coli" Pharmaceuticals 17, no. 5: 545. https://doi.org/10.3390/ph17050545

APA Style

Bessalah, S., Faraz, A., Dbara, M., Khorcheni, T., Hammadi, M., Ajose, D. J., & Saeed, S. I. (2024). Antibacterial, Anti-Biofilm, and Anti-Inflammatory Properties of Gelatin–Chitosan–Moringa-Biopolymer-Based Wound Dressings towards Staphylococcus aureus and Escherichia coli. Pharmaceuticals, 17(5), 545. https://doi.org/10.3390/ph17050545

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