Next Article in Journal
Diethyl (2-(4-Phenyl-1H-1,2,3-triazol-1-yl)benzyl) Phosphate
Previous Article in Journal
2-Cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one
Short Note

Synthesis and Cytotoxic Potential of 3-oxo-19β-Trifluoroacetoxy-18αH-oleane-28-oic Acid

Ufa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Sciences, 71 pr. Oktyabrya, 450054 Ufa, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Fang-Rong Chang
Molbank 2021, 2021(2), M1222; https://doi.org/10.3390/M1222
Received: 23 April 2021 / Revised: 18 May 2021 / Accepted: 21 May 2021 / Published: 1 June 2021
(This article belongs to the Section Natural Products)
Trifluoroacetic acid-promoted Wagner-Meerwein rearrangement of betulonic acid carboxamide led to the formation of the expected 19β,28-lactam along with a new germanicane-type 3-oxo-19β-trifluoroacetoxy-18αH-oleane-28-oic acid. The structure of this triterpenoid was confirmed by 2D NMR analyses. A primary evaluation of biological potency revealed an anticancer activity with GI50 < 5 μM against leukemia, colon cancer, breast cancer, and prostate cancer cell lines, while the parent compounds were not active. View Full-Text
Keywords: triterpenoids; lupane; betulin; oleanane; allobetulin; germanicane; Wagner–Meerwein rearrangement; cytotoxic activity; NCI-60 triterpenoids; lupane; betulin; oleanane; allobetulin; germanicane; Wagner–Meerwein rearrangement; cytotoxic activity; NCI-60
Show Figures

Graphical abstract

MDPI and ACS Style

Khusnutdinova, E.F.; Poptsov, A.I.; Kazakova, O.B. Synthesis and Cytotoxic Potential of 3-oxo-19β-Trifluoroacetoxy-18αH-oleane-28-oic Acid. Molbank 2021, 2021, M1222. https://doi.org/10.3390/M1222

AMA Style

Khusnutdinova EF, Poptsov AI, Kazakova OB. Synthesis and Cytotoxic Potential of 3-oxo-19β-Trifluoroacetoxy-18αH-oleane-28-oic Acid. Molbank. 2021; 2021(2):M1222. https://doi.org/10.3390/M1222

Chicago/Turabian Style

Khusnutdinova, Elmira F.; Poptsov, Alexander I.; Kazakova, Oxana B. 2021. "Synthesis and Cytotoxic Potential of 3-oxo-19β-Trifluoroacetoxy-18αH-oleane-28-oic Acid" Molbank 2021, no. 2: M1222. https://doi.org/10.3390/M1222

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop