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Aix Marseille Univ, CNRS, ICR UMR 7273, Equipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, CEDEX 05, 13385 Marseille, France
Authors to whom correspondence should be addressed.
Academic Editor: Luke R. Odell
Molbank 2021, 2021(2), M1221;
Received: 7 May 2021 / Revised: 20 May 2021 / Accepted: 26 May 2021 / Published: 1 June 2021
(This article belongs to the Section Organic Synthesis)
As part of our ongoing scaffold hopping work on antimalarial 2-aminothieno[3,2-d]pyrimidin-4-one scaffold, we explored the dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one as a potential new antimalarial series. Using conditions found in the literature, we obtained 2-cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one with 93% yield through a simple treatment. It was then characterized by NMR (1H and 13C) and HRMS. Given the structure of this molecule, its aqueous stability was assessed to determine its suitability for biological tests. To our knowledge, this is the first dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one described. View Full-Text
Keywords: boron; diazaborininone; thiophene; aqueous stability boron; diazaborininone; thiophene; aqueous stability
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MDPI and ACS Style

Mustière, R.; Vanelle, P.; Primas, N. 2-Cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one. Molbank 2021, 2021, M1221.

AMA Style

Mustière R, Vanelle P, Primas N. 2-Cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one. Molbank. 2021; 2021(2):M1221.

Chicago/Turabian Style

Mustière, Romain; Vanelle, Patrice; Primas, Nicolas. 2021. "2-Cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one" Molbank 2021, no. 2: M1221.

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