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(22E,24S)-24-Propylcholest-5en-3α-acetate: A New Steroid from the Stembark Aglaia angustifolia (Miq.) (Meliaceae)

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Department of Chemistry, Faculty of Mathematics and Natural Sciences, Nusa Bangsa University, Bogor 16166, West Java, Indonesia
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Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, West Java, Indonesia
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Central Laboratory, Universitas Padjadjaran, Jatinangor 45363, West Java, Indonesia
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Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sam Ratulangi, Kampus Bahu, Manado 95115, North Sulawesi, Indonesia
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Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 59100, Malaysia
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Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan
*
Author to whom correspondence should be addressed.
Molbank 2020, 2020(1), M1112; https://doi.org/10.3390/M1112
Received: 18 December 2019 / Revised: 21 January 2020 / Accepted: 22 January 2020 / Published: 28 January 2020
(This article belongs to the Section Natural Products)
A new propylcholesterol-type steroid, namely (22E,24S)-24-propylcholest-5en-3α-acetate (1), has been isolated from the stembark of Aglaia angustifolia (Miq.). The structure of 1 was determined on the basis of spectroscopic data including 1D- and 2D-NMR as well as high resolution mass spectroscopy analysis. Compound 1 showed weak activity against the MCF-7 breast cancer cell line.
Keywords: Aglaia angustifolia; Meliaceae; MCF-7; propylcholesterol Aglaia angustifolia; Meliaceae; MCF-7; propylcholesterol
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Hutagaol, R.P.; Harneti, D.; Hidayat, A.T.; Nurlelasari; Maharani, R.; Katja, D.G.; Supratman, U.; Awang, K.; Shiono, Y. (22E,24S)-24-Propylcholest-5en-3α-acetate: A New Steroid from the Stembark Aglaia angustifolia (Miq.) (Meliaceae). Molbank 2020, 2020, M1112.

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