(22E,24S)-24-Propylcholest-5en-3α-acetate: A New Steroid from the Stembark Aglaia angustifolia (Miq.) (Meliaceae)
by
Ricson P. Hutagaol 1,2, Desi Harneti 2, Ace T. Hidayat 2,3, Nurlelasari 2, Rani Maharani 2,3, Dewa Gede Katja 4, Unang Supratman 2,3,*, Khalijah Awang 5 and Yoshihito Shiono 6
Ricson P. Hutagaol 1,2, Desi Harneti 2, Ace T. Hidayat 2,3, Nurlelasari 2, Rani Maharani 2,3, Dewa Gede Katja 4, Unang Supratman 2,3,*, Khalijah Awang 5 and Yoshihito Shiono 6
1
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Nusa Bangsa University, Bogor 16166, West Java, Indonesia
2
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, West Java, Indonesia
3
Central Laboratory, Universitas Padjadjaran, Jatinangor 45363, West Java, Indonesia
4
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sam Ratulangi, Kampus Bahu, Manado 95115, North Sulawesi, Indonesia
5
Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 59100, Malaysia
6
Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan
*
Author to whom correspondence should be addressed.
Molbank 2020, 2020(1), M1112; https://doi.org/10.3390/M1112
Received: 18 December 2019 / Revised: 21 January 2020 / Accepted: 22 January 2020 / Published: 28 January 2020
(This article belongs to the Section Natural Products)
A new propylcholesterol-type steroid, namely (22E,24S)-24-propylcholest-5en-3α-acetate (1), has been isolated from the stembark of Aglaia angustifolia (Miq.). The structure of 1 was determined on the basis of spectroscopic data including 1D- and 2D-NMR as well as high resolution mass spectroscopy analysis. Compound 1 showed weak activity against the MCF-7 breast cancer cell line.
Keywords:
Aglaia angustifolia; Meliaceae; MCF-7; propylcholesterol
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MDPI and ACS Style
Hutagaol, R.P.; Harneti, D.; Hidayat, A.T.; Nurlelasari; Maharani, R.; Katja, D.G.; Supratman, U.; Awang, K.; Shiono, Y. (22E,24S)-24-Propylcholest-5en-3α-acetate: A New Steroid from the Stembark Aglaia angustifolia (Miq.) (Meliaceae). Molbank 2020, 2020, M1112.
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