Next Article in Journal
(E)-(1-(4-Ethoxycarbonylphenyl)-5-(3,4-dimethoxyphenyl)-3-(3,4-dimethoxystyryl)-2-pyrazoline: Synthesis, Characterization, DNA-Interaction, and Evaluation of Activity Against Drug-Resistant Cell Lines
Next Article in Special Issue
Diethyl Pyrrole-2,5-Dicarboxylate
Previous Article in Journal
(22E,24S)-24-Propylcholest-5en-3α-acetate: A New Steroid from the Stembark Aglaia angustifolia (Miq.) (Meliaceae)
Previous Article in Special Issue
Novel One-Pot Synthesis of Methyl 4-Hydroxy-2-thioxo-1,2-dihydroquinoline-3-carboxylate: Synthetic and Crystallographic Studies
Open AccessCommunication

1-Phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: Synthesis, Crystal Structure and Anti-Leukemic Activity

1
University of Bordeaux, Faculty of Pharmacy, INSERM U1212 / UMR CNRS 5320, ARNA Laboratory, 146 rue Léo Saignat, F-33076 Bordeaux CEDEX, France
2
University of Bordeaux, ISM—CNRS UMR 5255, F-33405 Talence CEDEX, France
3
CNRS, University of Bordeaux, Bordeaux INP, ICMCB, UMR 5026, F-33600 Pessac, France
4
University of Bordeaux, Faculty of Pharmacy, INSERM U1035, 146 rue Léo Saignat, F-33076 Bordeaux CEDEX, France
*
Author to whom correspondence should be addressed.
Molbank 2020, 2020(1), M1113; https://doi.org/10.3390/M1113
Received: 13 January 2020 / Revised: 21 January 2020 / Accepted: 24 January 2020 / Published: 29 January 2020
(This article belongs to the Special Issue Heterocycle Reactions)
1-Phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one has been successfully synthesized via a multi-step pathway starting from 2-nitroaniline. Structure characterization of this original pyrrolo[1,2-a]quinoxaline derivative was achieved by FT-IR, 1H-NMR, 13C-NMR, X-Ray and HRMS spectral analysis. This title compound shows interesting cytotoxic potential against several human leukemia cell lines (K562, HL60, and U937 cells).
Keywords: pyrrolo[1,2-a]quinoxaline derivative; leukemia; antiproliferative activity pyrrolo[1,2-a]quinoxaline derivative; leukemia; antiproliferative activity
Show Figures

Graphical abstract

MDPI and ACS Style

Guillon, J.; Savrimoutou, S.; Rubio, S.; Moreau, S.; Pinaud, N.; Marchivie, M.; Desplat, V. 1-Phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: Synthesis, Crystal Structure and Anti-Leukemic Activity. Molbank 2020, 2020, M1113.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop