Next Article in Journal
(2-Deoxy-2-{[2-(2-pyridinyl-κN)-4-thiazolecarbonyl-κN3]amino}-α-d-glucopyranose)dichloropalladium(II) Methanol Solvate
Previous Article in Journal
Crystal Structure of Bis(2,4,6-trimethylphenyl)-phosphine Oxide
Open AccessShort Note

Methyl N-[1-(Benzoylamino)-2-methoxy-2-oxoethyl]-tryptophanate

Organic Chemistry Laboratory (LCO), Faculty of Sciences Dhar El Mahraz–Sidi Mohammed Ben Abdellah University, Fez 30000, Morocco
Regional Center for Agronomic Research of Rabat, INRA-Rabat, Rabat 10000, Morocco
Author to whom correspondence should be addressed.
Molbank 2017, 2017(4), M958;
Received: 17 August 2017 / Revised: 8 September 2017 / Accepted: 12 September 2017 / Published: 22 September 2017
(This article belongs to the Section Organic Synthesis)
The title compound, methyl N-[1-(benzoylamino)-2-methoxy-2-oxoethyl]tryptophanate 2, was synthesized in high yield, via N-alkylation reaction of methyl 2-azido-2-benzamidoacetate with methyl 2-amino-3-(1H-indol-3-yl)propanoate in acetone, with the presence of diisopropylethylamine as a base. The structure of the prepared compound was characterized by 1H, 13C NMR in addition to MS, X-Ray diffraction data, and elemental analysis. This compound was tested in vitro for its antibacterial activity against Gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus, and Gram-negative bacteria, Escherichia coli, Pseudomonas aeruginosa, and Salmonella enteric. The MIC values showed that the synthesized compound had a bactericidal effect against the strains tested. View Full-Text
Keywords: antibacterial activity; carboxylic amino esters; N-alkylation antibacterial activity; carboxylic amino esters; N-alkylation
MDPI and ACS Style

Karai, O.; El Hamdani, M.; Faraj, H.; Alami, A.; Kabbour, M.R.; El Hallaoui, A.; Bouksaim, M.; Aouine, Y. Methyl N-[1-(Benzoylamino)-2-methoxy-2-oxoethyl]-tryptophanate. Molbank 2017, 2017, M958.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop