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International Journal of Molecular Sciences, Volume 25, Issue 9

2024 May-1 - 478 articles

Cover Story: Janus kinase inhibitors (JAKis) are small molecules that have shown great promise in the treatment of psoriasis and psoriatic arthritis. JAKis seem to be as efficient as other well-established treatments for these highly-prevalent inflammatory conditions and have led to the improvement of cutaneous and articular manifestations, systemic inflammation and quality of life, while maintaining an acceptable safety profile. JAKis act by blocking the evolutionarily conserved Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway involved in downstream signaling for cytokines using type I or II receptors. This scoping review aims to provide an integrated understanding of the range of effects that JAKis have on the whole spectrum of psoriasis manifestations. View this paper
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Articles (478)

  • Retraction
  • Open Access
2,778 Views
2 Pages

RETRACTED: Serebrovska et al. Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer’s Disease in Patients with Mild Cognitive Impairment: A Pilot Study. Int. J. Mol. Sci. 2019, 20, 5405

  • Zoya O. Serebrovska,
  • Tetiana V. Serebrovska,
  • Viktor A. Kholin,
  • Lesya V. Tumanovska,
  • Angela M. Shysh,
  • Denis A. Pashevin,
  • Sergii V. Goncharov,
  • Dmytro Stroy,
  • Oksana N. Grib and
  • Victor E. Dosenko
  • + 4 authors

The journal Int [...]

  • Article
  • Open Access
16 Citations
3,807 Views
28 Pages

Drought and salinity stress reduce root hydraulic conductivity of plant seedlings, and melatonin application positively mitigates stress-induced damage. However, the underlying effect of melatonin priming on root hydraulic conductivity of seedlings u...

  • Article
  • Open Access
4 Citations
3,446 Views
21 Pages

Retinoic Acid-Mediated Control of Energy Metabolism Is Essential for Lung Branching Morphogenesis

  • Hugo Fernandes-Silva,
  • Marco G. Alves,
  • Marcia R. Garcez,
  • Jorge Correia-Pinto,
  • Pedro F. Oliveira,
  • Catarina C. F. Homem and
  • Rute S. Moura

Lung branching morphogenesis relies on intricate epithelial–mesenchymal interactions and signaling networks. Still, the interplay between signaling and energy metabolism in shaping embryonic lung development remains unexplored. Retinoic acid (R...

  • Article
  • Open Access
10 Citations
3,348 Views
15 Pages

Clinicopathological Significance of Cyclin-Dependent Kinase 2 (CDK2) in Ductal Carcinoma In Situ and Early-Stage Invasive Breast Cancers

  • Ayat Lashen,
  • Shatha Alqahtani,
  • Ahmed Shoqafi,
  • Mashael Algethami,
  • Jennie N. Jeyapalan,
  • Nigel P. Mongan,
  • Emad A. Rakha and
  • Srinivasan Madhusudan

Cyclin-dependent kinase 2 (CDK2) is a key cell cycle regulator, with essential roles during G1/S transition. The clinicopathological significance of CDK2 in ductal carcinomas in situ (DCIS) and early-stage invasive breast cancers (BCs) remains largel...

  • Article
  • Open Access
6 Citations
2,632 Views
18 Pages

Genome-Wide Identification and Expression Profile Analysis of the Phenylalanine Ammonia-Lyase Gene Family in Hevea brasiliensis

  • Hui Liu,
  • Qiguang He,
  • Yiyu Hu,
  • Ruilin Lu,
  • Shuang Wu,
  • Chengtian Feng,
  • Kun Yuan and
  • Zhenhui Wang

The majority of the world’s natural rubber comes from the rubber tree (Hevea brasiliensis). As a key enzyme for synthesizing phenylpropanoid compounds, phenylalanine ammonia-lyase (PAL) has a critical role in plant satisfactory growth and envir...

  • Article
  • Open Access
3 Citations
2,689 Views
17 Pages

Anti-Biofilm Activity of Oleacein and Oleocanthal from Extra-Virgin Olive Oil toward Pseudomonas aeruginosa

  • Marisa Di Pietro,
  • Simone Filardo,
  • Roberto Mattioli,
  • Giuseppina Bozzuto,
  • Giammarco Raponi,
  • Luciana Mosca and
  • Rosa Sessa

New antimicrobial molecules effective against Pseudomonas aeruginosa, known as an antibiotic-resistant “high-priority pathogen”, are urgently required because of its ability to develop biofilms related to healthcare-acquired infections. I...

  • Article
  • Open Access
5 Citations
2,599 Views
19 Pages

Rice (Oryza sativa) is one of the most important staple foods worldwide. However, rice blast disease, caused by the ascomycete fungus Magnaporthe oryzae, seriously affects the yield and quality of rice. Calmodulin-binding transcriptional activators (...

  • Article
  • Open Access
5 Citations
3,965 Views
23 Pages

Natural Compounds for Bone Remodeling: A Computational and Experimental Approach Targeting Bone Metabolism-Related Proteins

  • Alexandros-Timotheos Loukas,
  • Michail Papadourakis,
  • Vasilis Panagiotopoulos,
  • Apostolia Zarmpala,
  • Eleni Chontzopoulou,
  • Stephanos Christodoulou,
  • Theodora Katsila,
  • Panagiotis Zoumpoulakis and
  • Minos-Timotheos Matsoukas

Osteoporosis, characterized by reduced bone density and increased fracture risk, affects over 200 million people worldwide, predominantly older adults and postmenopausal women. The disruption of the balance between bone-forming osteoblasts and bone-r...

  • Article
  • Open Access
3 Citations
2,191 Views
16 Pages

Complexes of Gold(III) with Hydrazones Derived from Pyridoxal: Stability, Structure, and Nature of UV-Vis Spectra

  • Natalia N. Kuranova,
  • Oleg A. Pimenov,
  • Maksim N. Zavalishin and
  • George A. Gamov

Pyridoxal and pyridoxal 5′-phosphate are aldehyde forms of B6 vitamin that can easily be transformed into each other in the living organism. The presence of a phosphate group, however, provides the related compounds (e.g., hydrazones) with bett...

  • Article
  • Open Access
4 Citations
2,129 Views
18 Pages

Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome

  • Iva Klobučar,
  • Hansjörg Habisch,
  • Lucija Klobučar,
  • Matias Trbušić,
  • Gudrun Pregartner,
  • Andrea Berghold,
  • Gerhard M. Kostner,
  • Hubert Scharnagl,
  • Tobias Madl and
  • Vesna Degoricija
  • + 1 author

Metabolic syndrome (MS) is a widespread disease in developed countries, accompanied, among others, by decreased adiponectin serum levels and perturbed lipoprotein metabolism. The associations between the serum levels of adiponectin and lipoproteins h...

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Int. J. Mol. Sci. - ISSN 1422-0067