You are currently viewing a new version of our website. To view the old version click .

International Journal of Molecular Sciences, Volume 24, Issue 4

February-2 2023 - 1196 articles

Cover Story: Lung macrophages (Mφs) are crucial for pulmonary defense due to their ability to dynamically switch their polarization between pro- and anti-inflammatory phenotypes. Mesenchymal stromal cells (MSCs) offer therapeutic promise for acute and chronic lung diseases, including COVID-19. MSCs exert immunomodulatory effects mainly through interaction with lung Mφs, reprogramming them and enhancing beneficial Mφ functions. Bidirectional MSC-Mφ communication is achieved via direct contact, soluble factor secretion/activation, and organelle transfer. Dynamic interactions between MSCs and Mφs shape the effects of MSCs on the injured lungs and are essential for the therapeutic impact. The lung microenvironment also plays a crucial role in defining MSC-Mφ crosstalk, determining the outcome of lung injury. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (1196)

  • Article
  • Open Access
7 Citations
3,715 Views
16 Pages

20 February 2023

Correct protein folding is the basis of cellular well-being; thus, accumulation of misfolded proteins within the endoplasmic reticulum (ER) leads to an imbalance of homeostasis that causes stress to the ER. Various studies have shown that protein mis...

  • Article
  • Open Access
3 Citations
5,912 Views
18 Pages

Microbiome Dysbiosis Shows Strong Association of Gut-Derived Altered Metabolomic Profile in Gulf War Chronic Multisymptom Illness Symptom Persistence Following Western Diet Feeding and Development of Obesity

  • Dipro Bose,
  • Vitalli Stebliankin,
  • Trevor Cickovski,
  • Punnag Saha,
  • Ayushi Trivedi,
  • Subhajit Roy,
  • Madhura More,
  • Ashok Tuteja,
  • Kalai Mathee and
  • Giri Narasimhan
  • + 1 author

20 February 2023

The pathophysiology of Gulf War Illness (GWI) remains elusive even after three decades. The persistence of multiple complex symptoms along with metabolic disorders such as obesity worsens the health of present Gulf War (GW) Veterans often by the inte...

  • Article
  • Open Access
4 Citations
3,377 Views
16 Pages

Metabolomic Insights of Biosurfactant Activity from Bacillus niabensis against Planktonic Cells and Biofilm of Pseudomonas stutzeri Involved in Marine Biofouling

  • Ilse Sánchez-Lozano,
  • Luz Clarita Muñoz-Cruz,
  • Claire Hellio,
  • Christine J. Band-Schmidt,
  • Yair Cruz-Narváez,
  • Elvia Becerra-Martínez and
  • Claudia J. Hernández-Guerrero

20 February 2023

In marine environments, biofilm can cause negative impacts, including the biofouling process. In the search for new non-toxic formulations that inhibit biofilm, biosurfactants (BS) produced by the genus Bacillus have demonstrated considerable potenti...

  • Review
  • Open Access
19 Citations
8,219 Views
18 Pages

20 February 2023

In recent decades, extracellular vesicles have been recognized as “very important particles” (VIPs) associated with aging and age-related disease. During the 1980s, researchers discovered that these vesicle particles released by cells wer...

  • Review
  • Open Access
8 Citations
7,378 Views
25 Pages

Potential Novel Role of Membrane-Associated Carbonic Anhydrases in the Kidney

  • Seong-Ki Lee,
  • Walter F. Boron and
  • Rossana Occhipinti

20 February 2023

Carbonic anhydrases (CAs), because they catalyze the interconversion of carbon dioxide (CO2) and water into bicarbonate (HCO3−) and protons (H+), thereby influencing pH, are near the core of virtually all physiological processes in the body. In...

  • Article
  • Open Access
3 Citations
3,092 Views
25 Pages

Exopolysaccharide Biosynthesis in Rhizobium leguminosarum bv. trifolii Requires a Complementary Function of Two Homologous Glycosyltransferases PssG and PssI

  • Kamil Żebracki,
  • Aleksandra Horbowicz,
  • Małgorzata Marczak,
  • Anna Turska-Szewczuk,
  • Piotr Koper,
  • Klaudia Wójcik,
  • Marceli Romańczuk,
  • Magdalena Wójcik and
  • Andrzej Mazur

20 February 2023

The Pss-I region of Rhizobium leguminosarum bv. trifolii TA1 comprises more than 20 genes coding for glycosyltransferases, modifying enzymes, and polymerization/export proteins, altogether determining the biosynthesis of symbiotically relevant exopol...

  • Article
  • Open Access
10 Citations
2,583 Views
13 Pages

20 February 2023

Saline-alkali stress is a major environmental stress affecting the growth and development of plants such as Sorbus pohuashanensis. Although ethylene plays a crucial role in plant response to saline-alkaline stress, its mechanism remains elusive. The...

  • Review
  • Open Access
10 Citations
4,226 Views
19 Pages

Peptide Designs for Use in Caries Management: A Systematic Review

  • Olivia Lili Zhang,
  • John Yun Niu,
  • Ollie Yiru Yu,
  • May Lei Mei,
  • Nicholas Stephen Jakubovics and
  • Chun Hung Chu

20 February 2023

The objective of this study was to review the design methods that have been used to create peptides for use in caries management. Two independent researchers systematically reviewed many in vitro studies in which peptides were designed for use in car...

  • Article
  • Open Access
7 Citations
3,779 Views
19 Pages

Nuclear High Mobility Group A2 (HMGA2) Interactome Revealed by Biotin Proximity Labeling

  • Antoine Gaudreau-Lapierre,
  • Thomas Klonisch,
  • Hannah Nicolas,
  • Thatchawan Thanasupawat,
  • Laura Trinkle-Mulcahy and
  • Sabine Hombach-Klonisch

20 February 2023

The non-histone chromatin binding protein High Mobility Group AT-hook protein 2 (HMGA2) has important functions in chromatin remodeling, and genome maintenance and protection. Expression of HMGA2 is highest in embryonic stem cells, declines during ce...

of 120

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Int. J. Mol. Sci. - ISSN 1422-0067