You are currently on the new version of our website. Access the old version .

International Journal of Molecular Sciences, Volume 23, Issue 15

2022 August-1 - 778 articles

Cover Story: The biosphere hosts innumerable life forms that thrive under high pressure. In particular, a multitude of these organisms populate the deep sea, which is reported to be the milieu where life originated. However, the mechanism of high-pressure adaptation still remains a mystery. Our study is the first to compare the structure and dynamics of two orthologous proteins in understanding these mechanisms at the atomic level. We demonstrate, in an unprecedented way, that conservative mutations of protein residues have a pivotal role in pressure adaptation and, thereby, in the evolution of life. Strikingly, we find that the decoupling of protein–water dynamics and alterations in the protein core cavities also play a major role. These findings provide profound insight in the search for a genomic model explaining high-pressure adaptation. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (778)

  • Article
  • Open Access
6 Citations
4,581 Views
15 Pages

Facile Microwave Assisted Synthesis of Silver Nanostars for Ultrasensitive Detection of Biological Analytes by SERS

  • Radu Nicolae Revnic,
  • Gabriela Fabiola Știufiuc,
  • Valentin Toma,
  • Anca Onaciu,
  • Alin Moldovan,
  • Adrian Bogdan Țigu,
  • Eva Fischer-Fodor,
  • Romulus Tetean,
  • Emil Burzo and
  • Rareș Ionuț Știufiuc

We report a very simple, rapid and reproducible method for the fabrication of anisotropic silver nanostars (AgNS) that can be successfully used as highly efficient SERS substrates for different bioanalytes, even in the case of a near-infra-red (NIR)...

  • Article
  • Open Access
1 Citations
2,858 Views
21 Pages

Incorporation of the New anti-Octadecaborane Laser Dyes into Thin Polymer Films: A Temperature-Dependent Photoluminescence and Infrared Spectroscopy Study

  • Tereza Capkova,
  • Barbora Hanulikova,
  • Jakub Sevcik,
  • Pavel Urbanek,
  • Jan Antos,
  • Michal Urbanek and
  • Ivo Kuritka

New anti-octadecaborane(22) laser dyes have been recently introduced. However, their application in solid thin films is limited, despite being very desirable for electronics. Spectroscopic methods, photoluminescence (PL), and infrared reflection&ndas...

  • Article
  • Open Access
9 Citations
4,449 Views
18 Pages

Smoltification (parr-smolt transformation) is a complex developmental process consisting of developmental changes that lead to remodeling of the Atlantic salmon gill. Here, the expression changes of miRNAs and mRNAs were studied by small-RNA sequenci...

  • Review
  • Open Access
7 Citations
5,508 Views
41 Pages

Forest Biomass as a Promising Source of Bioactive Essential Oil and Phenolic Compounds for Alzheimer’s Disease Therapy

  • Patrícia Moreira,
  • Patrícia Matos,
  • Artur Figueirinha,
  • Lígia Salgueiro,
  • Maria Teresa Batista,
  • Pedro Costa Branco,
  • Maria Teresa Cruz and
  • Cláudia Fragão Pereira

Alzheimer’s disease (AD) is the most common neurodegenerative disorder affecting elderly people worldwide. Currently, there are no effective treatments for AD able to prevent disease progression, highlighting the urgency of finding new therapeu...

  • Case Report
  • Open Access
15 Citations
5,320 Views
7 Pages

Autism spectrum disorder (ASD) is often associated with several intestinal and/or metabolic disorders as well as neurological manifestations such as epilepsy (ASD-E). Those presenting these neuropathological conditions share common aspects in terms o...

  • Article
  • Open Access
6 Citations
3,363 Views
17 Pages

Deletion of Meg8-DMR Enhances Migration and Invasion of MLTC-1 Depending on the CTCF Binding Sites

  • Xiao Han,
  • Hongjuan He,
  • Lan Shao,
  • Shuang Cui,
  • Haoran Yu,
  • Ximeijia Zhang and
  • Qiong Wu

The Dlk1-Dio3 imprinted domain on mouse chromosome 12 contains three well-characterized paternally methylated differentially methylated regions (DMRs): IG-DMR, Gtl2-DMR, and Dlk1-DMR. These DMRs control the expression of many genes involved in embryo...

  • Review
  • Open Access
5 Citations
4,301 Views
18 Pages

Extracellular Vesicles in Myeloid Neoplasms

  • Christina Karantanou,
  • Valentina René Minciacchi and
  • Theodoros Karantanos

Myeloid neoplasms arise from malignant primitive cells, which exhibit growth advantage within the bone marrow microenvironment (BMM). The interaction between these malignant cells and BMM cells is critical for the progression of these diseases. Extra...

  • Article
  • Open Access
5 Citations
3,813 Views
12 Pages

Salicylaldehyde Suppresses IgE-Mediated Activation of Mast Cells and Ameliorates Anaphylaxis in Mice

  • Tsubasa Ashikari,
  • Masakazu Hachisu,
  • Kazuki Nagata,
  • Daisuke Ando,
  • Yuki Iizuka,
  • Naoto Ito,
  • Kandai Ito,
  • Yuki Ikeda,
  • Hiroki Matsubara and
  • Chiharu Nishiyama
  • + 2 authors

Mast cells (MCs) play key roles in IgE-mediated immunoresponses, including in the protection against parasitic infections and the onset and/or symptoms of allergic diseases. IgE-mediated activation induces MCs to release mediators, including histamin...

  • Article
  • Open Access
15 Citations
3,104 Views
14 Pages

OsWRKY114 Inhibits ABA-Induced Susceptibility to Xanthomonas oryzae pv. oryzae in Rice

  • Seungmin Son,
  • Jong Hee Im,
  • Giha Song,
  • Suhyeon Nam and
  • Sang Ryeol Park

The phytohormone abscisic acid (ABA) regulates various aspects of plant growth, development, and stress responses. ABA suppresses innate immunity to Xanthomonas oryzae pv. oryzae (Xoo) in rice (Oryza sativa), but the identity of the underlying regula...

  • Article
  • Open Access
9 Citations
3,575 Views
19 Pages

Stellettin B-Induced Oral Cancer Cell Death via Endoplasmic Reticulum Stress–Mitochondrial Apoptotic and Autophagic Signaling Pathway

  • Tsu-Jen Kuo,
  • Yen-Hsuan Jean,
  • Po-Chang Shih,
  • Shu-Yu Cheng,
  • Hsiao-Mei Kuo,
  • Yi-Ting Lee,
  • Yu-Cheng Lai,
  • Chung-Chih Tseng,
  • Wu-Fu Chen and
  • Zhi-Hong Wen

Oral squamous cell carcinoma (OSCC) affects tens of thousands of people worldwide. Despite advances in cancer treatment, the 5-year survival rate of patients with late-stage OSCC is low at 50–60%. Therefore, the development of anti-OSCC therapy...

of 78

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Int. J. Mol. Sci. - ISSN 1422-0067