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Skin Barrier Dysregulation in Psoriasis
Review

Five Functional Aspects of the Epidermal Barrier

1
Sce de Pédiatrie Générale et Urgence pédiatrique, Hôpital Jean Verdier, Assistance Publique Hôpitaux de Paris, 93140 Bondy, France
2
Unité 976 HIPI, Institut de Recherche Saint-Louis, Université de Paris, Inserm, 75010, Paris, France
3
Centre international de Recherche en Infectiologie, Inserm U1111, Université Claude Bernard Lyon 1, 69007 Lyon, France
4
Sce de Pneumologie Pédiatrique et Allergie, Hôpital Femme Mère Enfant, 69500 Bron, France
5
CNRS UMR5305, Laboratory of Tissue Biology and Therapeutic Engineering, LBTI, Lyon1 University, 69100 Lyon, France
6
Inserm U1098, Université de Franche Comté, 25000 Besançon, France
7
Sce de Dermatologie, Centre Hospitalier Universitaire, 25000 Besançon, France
*
Author to whom correspondence should be addressed.
Authors contributed equally.
Academic Editor: Kyung-Min Lim
Int. J. Mol. Sci. 2021, 22(21), 11676; https://doi.org/10.3390/ijms222111676
Received: 4 August 2021 / Revised: 24 October 2021 / Accepted: 25 October 2021 / Published: 28 October 2021
(This article belongs to the Special Issue Skin Epidermis and Barrier Function 2.0)
The epidermis is a living, multilayered barrier with five functional levels, including a physical, a chemical, a microbial, a neuronal, and an immune level. Altogether, this complex organ contributes to protect the host from external aggression and to preserve its integrity. In this review, we focused on the different functional aspects. View Full-Text
Keywords: epidermis; skin barrier; stratum corneum; ceramides; keratinization; desmosomes; tight junctions; immunity; sensory nerves; microbiome epidermis; skin barrier; stratum corneum; ceramides; keratinization; desmosomes; tight junctions; immunity; sensory nerves; microbiome
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MDPI and ACS Style

Lefèvre-Utile, A.; Braun, C.; Haftek, M.; Aubin, F. Five Functional Aspects of the Epidermal Barrier. Int. J. Mol. Sci. 2021, 22, 11676. https://doi.org/10.3390/ijms222111676

AMA Style

Lefèvre-Utile A, Braun C, Haftek M, Aubin F. Five Functional Aspects of the Epidermal Barrier. International Journal of Molecular Sciences. 2021; 22(21):11676. https://doi.org/10.3390/ijms222111676

Chicago/Turabian Style

Lefèvre-Utile, Alain, Camille Braun, Marek Haftek, and François Aubin. 2021. "Five Functional Aspects of the Epidermal Barrier" International Journal of Molecular Sciences 22, no. 21: 11676. https://doi.org/10.3390/ijms222111676

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