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Article

The Role of Gold Nanorods in the Response of Prostate Cancer and Normal Prostate Cells to Ionizing Radiation—In Vitro Model

1
Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Centre, 61-866 Poznań, Poland
2
Department of Macromolecular Physics, Faculty of Physics, Adam Mickiewicz University, 61-614 Poznań, Poland
3
Department of Electroradiology, Poznan University of Medical Sciences, 61-701 Poznań, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(1), 16; https://doi.org/10.3390/ijms22010016
Received: 17 November 2020 / Revised: 2 December 2020 / Accepted: 17 December 2020 / Published: 22 December 2020
(This article belongs to the Special Issue Bio-Nano Interactions)
To increase the efficiency of therapy via enhancing its selectivity, the usage of gold nanorods (GNR) as a factor sensitizing cancer cells to radiation was proposed. Due to gold nanoparticles’ characteristics, the smaller doses of radiation would be sufficient in the treatment, protecting the healthy tissue around the tumor. The aim of this study was to investigate the effect of gold nanorods on cancer and normal prostate cells and the role of nanorods in the cell response to ionizing radiation. The effect was evaluated by measuring the toxicity, cell cycle, cell granularity, reactive oxygen species (ROS) level, and survival fractions. Nanorods showed a strong toxicity dependent on the concentration and incubation time toward all used cell lines. A slight effect of nanorods on the cycle distribution was observed. The results demonstrated that the administration of nanorods at higher concentrations resulted in an increased level of generated radicals. The results of cellular proliferation after irradiation are ambiguous; however, there are noticeable differences after the application of nanorods before irradiation. The obtained results lead to the conclusion that nanorods affect the physiology of both normal and cancer cells. Nanorods might become a potential tool used to increase the effectiveness of radiation treatment View Full-Text
Keywords: gold nanorods; nanoparticles; radiotherapy; prostate cancer; radiosensitivity gold nanorods; nanoparticles; radiotherapy; prostate cancer; radiosensitivity
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MDPI and ACS Style

Musielak, M.; Boś-Liedke, A.; Piotrowski, I.; Kozak, M.; Suchorska, W. The Role of Gold Nanorods in the Response of Prostate Cancer and Normal Prostate Cells to Ionizing Radiation—In Vitro Model. Int. J. Mol. Sci. 2021, 22, 16. https://doi.org/10.3390/ijms22010016

AMA Style

Musielak M, Boś-Liedke A, Piotrowski I, Kozak M, Suchorska W. The Role of Gold Nanorods in the Response of Prostate Cancer and Normal Prostate Cells to Ionizing Radiation—In Vitro Model. International Journal of Molecular Sciences. 2021; 22(1):16. https://doi.org/10.3390/ijms22010016

Chicago/Turabian Style

Musielak, Marika, Agnieszka Boś-Liedke, Igor Piotrowski, Maciej Kozak, and Wiktoria Suchorska. 2021. "The Role of Gold Nanorods in the Response of Prostate Cancer and Normal Prostate Cells to Ionizing Radiation—In Vitro Model" International Journal of Molecular Sciences 22, no. 1: 16. https://doi.org/10.3390/ijms22010016

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