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A Newly Created Meso-, Micro-, and Nano-Scale Rough Titanium Surface Promotes Bone-Implant Integration
Article

UV-Photofunctionalization of Titanium Promotes Mechanical Anchorage in A Rat Osteoporosis Model

1
Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, UCLA School of Dentistry, Los Angeles, CA 90095-1668, USA
2
Department of Orthopedic Surgery, Yokohama City Minato Red Cross Hospital, 3-12-1 Shinyamashita, Yokohama 231-8682, Kanagawa, Japan
3
Department of Oral Science, Graduate School of Dentistry, Kanagawa Dental University, 82 Inaoka, Yokosuka 238-8580, Kanagawa, Japan
4
Department of Oral and Maxillofacial Surgery/Orthodontics, Yokohama City University Medical Center, 4-57 Urafune-cho, Yokohama 232-0024, Kanagawa, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(4), 1235; https://doi.org/10.3390/ijms21041235
Received: 30 December 2019 / Revised: 6 February 2020 / Accepted: 11 February 2020 / Published: 12 February 2020
(This article belongs to the Special Issue Functional Materials for Bone Regeneration: Biomaterials and Cells)
Effects of UV-photofunctionalization on bone-to-titanium integration under challenging systemic conditions remain unclear. We examined the behavior and response of osteoblasts from sham-operated and ovariectomized (OVX) rats on titanium surfaces with or without UV light pre-treatment and the strength of bone-implant integration. Osteoblasts from OVX rats showed significantly lower alkaline phosphatase, osteogenic gene expression, and mineralization activities than those from sham rats. Bone density variables in the spine were consistently lower in OVX rats. UV-treated titanium was superhydrophilic and the contact angle of ddH2O was ≤5°. Titanium without UV treatment was hydrophobic with a contact angle of ≥80°. Initial attachment to titanium, proliferation, alkaline phosphatase activity, and gene expression were significantly increased on UV-treated titanium compared to that on control titanium in osteoblasts from sham and OVX rats. Osteoblastic functions compromised by OVX were elevated to levels equivalent to or higher than those of sham-operated osteoblasts following culture on UV-treated titanium. The strength of in vivo bone-implant integration for UV-treated titanium was 80% higher than that of control titanium in OVX rats and even higher than that of control implants in sham-operated rats. Thus, UV-photofunctionalization effectively enhanced bone-implant integration in OVX rats to overcome post-menopausal osteoporosis-like conditions. View Full-Text
Keywords: titanium; osteoblast; osteoporosis; UV light treatment; bone regeneration; ovariectomy; bone integration; mechanical anchorage; dental implants; orthopedic implants titanium; osteoblast; osteoporosis; UV light treatment; bone regeneration; ovariectomy; bone integration; mechanical anchorage; dental implants; orthopedic implants
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MDPI and ACS Style

Taniyama, T.; Saruta, J.; Mohammadzadeh Rezaei, N.; Nakhaei, K.; Ghassemi, A.; Hirota, M.; Okubo, T.; Ikeda, T.; Sugita, Y.; Hasegawa, M.; Ogawa, T. UV-Photofunctionalization of Titanium Promotes Mechanical Anchorage in A Rat Osteoporosis Model. Int. J. Mol. Sci. 2020, 21, 1235. https://doi.org/10.3390/ijms21041235

AMA Style

Taniyama T, Saruta J, Mohammadzadeh Rezaei N, Nakhaei K, Ghassemi A, Hirota M, Okubo T, Ikeda T, Sugita Y, Hasegawa M, Ogawa T. UV-Photofunctionalization of Titanium Promotes Mechanical Anchorage in A Rat Osteoporosis Model. International Journal of Molecular Sciences. 2020; 21(4):1235. https://doi.org/10.3390/ijms21041235

Chicago/Turabian Style

Taniyama, Takashi, Juri Saruta, Naser Mohammadzadeh Rezaei, Kourosh Nakhaei, Amirreza Ghassemi, Makoto Hirota, Takahisa Okubo, Takayuki Ikeda, Yoshihiko Sugita, Masakazu Hasegawa, and Takahiro Ogawa. 2020. "UV-Photofunctionalization of Titanium Promotes Mechanical Anchorage in A Rat Osteoporosis Model" International Journal of Molecular Sciences 21, no. 4: 1235. https://doi.org/10.3390/ijms21041235

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