Int. J. Mol. Sci., Volume 21, Issue 23 (December-1 2020) – 452 articles
Cover Story (view full-size image): Tumors are heterogeneous tissues with tumor cells and cells of the tumor microenvironment. During malignant progression, tumors locally recruit immune cells that reject but also promote tumor growth and metastasis. The infiltrated immune cells express components of the endocannabinoid system, thereby forming an “immune-endocannabinoid system” within the tumor microenvironment. The review article by Kienzl et al. describes the role of immune cells in the tumor microenvironment and discusses the possibility that members of the endocannabinoid system, in particular, the cannabinoid receptors, endocannabinoids like 2-AG, and the enzymes for endocannabinoid degradation, may critically contribute to the shape of the microenvironment and thus to tumor progression. View this paper
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