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Article

Genomic Instability Is an Early Event in Aluminium-Induced Tumorigenesis

1
Laboratoire de Cancérogenèse Environnementale, Fondation des Grangettes, 1224 Chêne-Bougeries, Switzerland
2
Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
3
Department of Pathology, Geneva University Hospital, 1205 Geneva, Switzerland
4
TransCure bioServices, 74160 Archamps, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(23), 9332; https://doi.org/10.3390/ijms21239332
Received: 14 October 2020 / Revised: 14 November 2020 / Accepted: 29 November 2020 / Published: 7 December 2020
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genomic instability is generally considered as a hallmark of tumorigenesis and a prerequisite condition for malignant transformation. Aluminium salts are suspected environmental carcinogens that transform mammary epithelial cells in vitro through unknown mechanisms. We report here that long-term culture in the presence of aluminium chloride (AlCl3) enables HC11 normal mouse mammary epithelial cells to form tumours and metastases when injected into the syngeneic and immunocompetent BALB/cByJ strain. We demonstrate that AlCl3 rapidly increases chromosomal structural abnormalities in mammary epithelial cells, while we failed to detect direct modulation of specific mRNA pathways. Our observations provide evidence that clastogenic activity—a well-recognized inducer of genomic instability—might account in part for the transforming abilities of aluminium in mammary epithelial cells. View Full-Text
Keywords: aluminium; breast cancer; carcinogenesis; genomic instability; clastogens aluminium; breast cancer; carcinogenesis; genomic instability; clastogens
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MDPI and ACS Style

Mandriota, S.J.; Tenan, M.; Nicolle, A.; Jankowska, J.D.; Ferrari, P.; Tille, J.-C.; Durin, M.-A.; Green, C.M.; Tabruyn, S.; Moralli, D.; Sappino, A.-P. Genomic Instability Is an Early Event in Aluminium-Induced Tumorigenesis. Int. J. Mol. Sci. 2020, 21, 9332. https://doi.org/10.3390/ijms21239332

AMA Style

Mandriota SJ, Tenan M, Nicolle A, Jankowska JD, Ferrari P, Tille J-C, Durin M-A, Green CM, Tabruyn S, Moralli D, Sappino A-P. Genomic Instability Is an Early Event in Aluminium-Induced Tumorigenesis. International Journal of Molecular Sciences. 2020; 21(23):9332. https://doi.org/10.3390/ijms21239332

Chicago/Turabian Style

Mandriota, Stefano J., Mirna Tenan, Adeline Nicolle, Julia D. Jankowska, Paolo Ferrari, Jean-Christophe Tille, Mary-Anne Durin, Catherine M. Green, Sebastien Tabruyn, Daniela Moralli, and André-Pascal Sappino. 2020. "Genomic Instability Is an Early Event in Aluminium-Induced Tumorigenesis" International Journal of Molecular Sciences 21, no. 23: 9332. https://doi.org/10.3390/ijms21239332

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