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Review

Herpes Simplex Virus Type 1 Interactions with the Interferon System

Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead NSW 2145, Australia
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(14), 5150; https://doi.org/10.3390/ijms21145150
Received: 2 July 2020 / Revised: 16 July 2020 / Accepted: 17 July 2020 / Published: 21 July 2020
(This article belongs to the Special Issue Herpes Simplex Virus: From Reactivation to Assembly)
The interferon (IFN) system is one of the first lines of defense activated against invading viral pathogens. Upon secretion, IFNs activate a signaling cascade resulting in the production of several interferon stimulated genes (ISGs), which work to limit viral replication and establish an overall anti-viral state. Herpes simplex virus type 1 is a ubiquitous human pathogen that has evolved to downregulate the IFN response and establish lifelong latent infection in sensory neurons of the host. This review will focus on the mechanisms by which the host innate immune system detects invading HSV-1 virions, the subsequent IFN response generated to limit viral infection, and the evasion strategies developed by HSV-1 to evade the immune system and establish latency in the host. View Full-Text
Keywords: herpes simplex virus; interferon; innate immunity; immune evasion herpes simplex virus; interferon; innate immunity; immune evasion
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MDPI and ACS Style

Danastas, K.; Miranda-Saksena, M.; Cunningham, A.L. Herpes Simplex Virus Type 1 Interactions with the Interferon System. Int. J. Mol. Sci. 2020, 21, 5150. https://doi.org/10.3390/ijms21145150

AMA Style

Danastas K, Miranda-Saksena M, Cunningham AL. Herpes Simplex Virus Type 1 Interactions with the Interferon System. International Journal of Molecular Sciences. 2020; 21(14):5150. https://doi.org/10.3390/ijms21145150

Chicago/Turabian Style

Danastas, Kevin, Monica Miranda-Saksena, and Anthony L. Cunningham 2020. "Herpes Simplex Virus Type 1 Interactions with the Interferon System" International Journal of Molecular Sciences 21, no. 14: 5150. https://doi.org/10.3390/ijms21145150

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