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Open AccessReview

Therapeutic Targets for Bone and Soft-Tissue Sarcomas

Department of Orthopaedic Surgery, Kanazawa University School of Medicine, Kanazawa 920-8640, Japan
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(1), 170; https://doi.org/10.3390/ijms20010170
Received: 13 November 2018 / Revised: 27 December 2018 / Accepted: 3 January 2019 / Published: 4 January 2019
(This article belongs to the Special Issue Current Advances in Soft Tissue and Bone Sarcoma)
Due to the rarity and heterogeneity of bone and soft-tissue sarcomas, investigation into molecular targets and new treatments has been particularly challenging. Although intensive chemotherapy and establishment of surgical procedures have improved the outcomes of patients with sarcoma, the curative rate of recurrent and metastatic sarcomas is still not satisfactory. Recent basic science research has revealed some of the mechanisms of progression and metastasis of malignancies including proliferation, apoptosis, angiogenesis, tumor microenvironment, migration, invasion, and regulation of antitumor immune systems. Based on these basic studies, new anticancer drugs, including pazopanib, trabectedin, eribulin, and immune checkpoint inhibitors have been developed and the efficacies and safety of the new drugs have been assessed by clinical trials. This review summarizes new molecular therapeutic targets and advances in the treatment for bone and soft tissue sarcomas. View Full-Text
Keywords: sarcoma; immunotherapy; chemotherapy sarcoma; immunotherapy; chemotherapy
MDPI and ACS Style

Miwa, S.; Yamamoto, N.; Hayashi, K.; Takeuchi, A.; Igarashi, K.; Tsuchiya, H. Therapeutic Targets for Bone and Soft-Tissue Sarcomas. Int. J. Mol. Sci. 2019, 20, 170. https://doi.org/10.3390/ijms20010170

AMA Style

Miwa S, Yamamoto N, Hayashi K, Takeuchi A, Igarashi K, Tsuchiya H. Therapeutic Targets for Bone and Soft-Tissue Sarcomas. International Journal of Molecular Sciences. 2019; 20(1):170. https://doi.org/10.3390/ijms20010170

Chicago/Turabian Style

Miwa, Shinji; Yamamoto, Norio; Hayashi, Katsuhiro; Takeuchi, Akihiko; Igarashi, Kentaro; Tsuchiya, Hiroyuki. 2019. "Therapeutic Targets for Bone and Soft-Tissue Sarcomas" Int. J. Mol. Sci. 20, no. 1: 170. https://doi.org/10.3390/ijms20010170

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