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Int. J. Mol. Sci. 2018, 19(5), 1468;

Immunomodulatory Function of Myeloid-Derived Suppressor Cells during B Cell-Mediated Immune Responses

School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 6 April 2018 / Revised: 3 May 2018 / Accepted: 12 May 2018 / Published: 15 May 2018
(This article belongs to the Special Issue B Cells and Immunological Tolerance)
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Myeloid-derived suppressor cells (MDSCs) play roles in immune regulation during neoplastic and non-neoplastic inflammatory responses. This immune regulatory function is directed mainly toward T cells. However, MDSCs also regulate other cell populations, including B cells, during inflammatory responses. Indeed, B cells are essential for antibody-mediated immune responses. MDSCs regulate B cell immune responses directly via expression of effector molecules and indirectly by controlling other immune regulatory cells. B cell-mediated immune responses are a major component of the overall immune response; thus, MDSCs play a prominent role in their regulation. Here, we review the current knowledge about MDSC-mediated regulation of B cell responses. View Full-Text
Keywords: MDSCs; B cells; inflammation; M-MDSCs; PMN-MDSCs MDSCs; B cells; inflammation; M-MDSCs; PMN-MDSCs

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Özkan, B.; Lim, H.; Park, S.-G. Immunomodulatory Function of Myeloid-Derived Suppressor Cells during B Cell-Mediated Immune Responses. Int. J. Mol. Sci. 2018, 19, 1468.

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