Immunomodulatory Function of Myeloid-Derived Suppressor Cells during B Cell-Mediated Immune Responses
School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2018, 19(5), 1468; https://doi.org/10.3390/ijms19051468
Received: 6 April 2018
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Revised: 3 May 2018
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Accepted: 12 May 2018
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Published: 15 May 2018
(This article belongs to the Special Issue B Cells and Immunological Tolerance)
Myeloid-derived suppressor cells (MDSCs) play roles in immune regulation during neoplastic and non-neoplastic inflammatory responses. This immune regulatory function is directed mainly toward T cells. However, MDSCs also regulate other cell populations, including B cells, during inflammatory responses. Indeed, B cells are essential for antibody-mediated immune responses. MDSCs regulate B cell immune responses directly via expression of effector molecules and indirectly by controlling other immune regulatory cells. B cell-mediated immune responses are a major component of the overall immune response; thus, MDSCs play a prominent role in their regulation. Here, we review the current knowledge about MDSC-mediated regulation of B cell responses.
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Keywords:
MDSCs; B cells; inflammation; M-MDSCs; PMN-MDSCs
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MDPI and ACS Style
Özkan, B.; Lim, H.; Park, S.-G. Immunomodulatory Function of Myeloid-Derived Suppressor Cells during B Cell-Mediated Immune Responses. Int. J. Mol. Sci. 2018, 19, 1468. https://doi.org/10.3390/ijms19051468
AMA Style
Özkan B, Lim H, Park S-G. Immunomodulatory Function of Myeloid-Derived Suppressor Cells during B Cell-Mediated Immune Responses. International Journal of Molecular Sciences. 2018; 19(5):1468. https://doi.org/10.3390/ijms19051468
Chicago/Turabian StyleÖzkan, Bilgenaz, Heejin Lim, and Sung-Gyoo Park. 2018. "Immunomodulatory Function of Myeloid-Derived Suppressor Cells during B Cell-Mediated Immune Responses" International Journal of Molecular Sciences 19, no. 5: 1468. https://doi.org/10.3390/ijms19051468
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