Next Article in Journal
Emerging Roles of p53 Family Members in Glucose Metabolism
Next Article in Special Issue
Effective Delivery of Arsenic Trioxide to HPV-Positive Cervical Cancer Cells Using Optimised Liposomes: A Size and Charge Study
Previous Article in Journal
Differential Inflammatory-Response Kinetics of Human Keratinocytes upon Cytosolic RNA- and DNA-Fragment Induction
Previous Article in Special Issue
Polymeric Nano-Micelles as Novel Cargo-Carriers for LY2157299 Liver Cancer Cells Delivery
 
 
Review

PEO-PPO-PEO Tri-Block Copolymers for Gene Delivery Applications in Human Regenerative Medicine—An Overview

1
Center of Experimental Orthopaedics, Saarland University Medical Center, Kirrbergerstr. Bldg 37, D-66421 Homburg/Saar, Germany
2
Centro de Investigacións Científicas Avanzadas (CICA), Universidade da Coruña, Campus de A Coruña, 15071 A Coruña, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(3), 775; https://doi.org/10.3390/ijms19030775
Received: 22 February 2018 / Revised: 3 March 2018 / Accepted: 6 March 2018 / Published: 8 March 2018
(This article belongs to the Special Issue Nanotechnology in Drug Delivery)
Lineal (poloxamers or Pluronic®) or X-shaped (poloxamines or Tetronic®) amphiphilic tri-block copolymers of poly(ethylene oxide) and poly(propylene oxide) (PEO-PPO-PEO) have been broadly explored for controlled drug delivery in different regenerative medicine approaches. The ability of these copolymers to self-assemble as micelles and to undergo sol-to-gel transitions upon heating has endowed the denomination of “smart” or “intelligent” systems. The use of PEO-PPO-PEO copolymers as gene delivery systems is a powerful emerging strategy to improve the performance of classical gene transfer vectors. This review summarizes the state of art of the application of PEO-PPO-PEO copolymers in both nonviral and viral gene transfer approaches and their potential as gene delivery systems in different regenerative medicine approaches. View Full-Text
Keywords: PEO-PPO-PEO copolymers; nonviral vectors; viral vectors; gene transfer PEO-PPO-PEO copolymers; nonviral vectors; viral vectors; gene transfer
Show Figures

Graphical abstract

MDPI and ACS Style

Rey-Rico, A.; Cucchiarini, M. PEO-PPO-PEO Tri-Block Copolymers for Gene Delivery Applications in Human Regenerative Medicine—An Overview. Int. J. Mol. Sci. 2018, 19, 775. https://doi.org/10.3390/ijms19030775

AMA Style

Rey-Rico A, Cucchiarini M. PEO-PPO-PEO Tri-Block Copolymers for Gene Delivery Applications in Human Regenerative Medicine—An Overview. International Journal of Molecular Sciences. 2018; 19(3):775. https://doi.org/10.3390/ijms19030775

Chicago/Turabian Style

Rey-Rico, Ana, and Magali Cucchiarini. 2018. "PEO-PPO-PEO Tri-Block Copolymers for Gene Delivery Applications in Human Regenerative Medicine—An Overview" International Journal of Molecular Sciences 19, no. 3: 775. https://doi.org/10.3390/ijms19030775

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop