Next Article in Journal
“Autoimmune(-Like)” Drug and Herb Induced Liver Injury: New Insights into Molecular Pathogenesis
Next Article in Special Issue
Autophagy and Inflammatory Response in the Tumor Microenvironment
Previous Article in Journal
An Insight into T-DNA Integration Events in Medicago sativa
Previous Article in Special Issue
Histone Deacetylase Inhibitor-Induced Autophagy in Tumor Cells: Implications for p53
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(9), 1959;

Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer

Division of Bioengineering, Incheon National University, Incheon 22012, Korea
Traditional Alcoholic Beverage Research Team, Korea Food Research Institute, Seongnam 13539, Korea
Advanced Institutes of Convergence Technology, Seoul National University, Suwon 16495, Korea
Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea
These authors contributed equally to this work
Author to whom correspondence should be addressed.
Received: 31 July 2017 / Revised: 10 September 2017 / Accepted: 11 September 2017 / Published: 12 September 2017
(This article belongs to the Special Issue Autophagy at the Intersection of the Immune System and Cancer)
Full-Text   |   PDF [272 KB, uploaded 13 September 2017]


Autophagy is an essential catabolic program that forms part of the stress response and enables cells to break down their own intracellular components within lysosomes for recycling. Accumulating evidence suggests that autophagy plays vital roles in determining pathological outcomes of immune responses and tumorigenesis. Autophagy regulates innate and adaptive immunity affecting the pathologies of infectious, inflammatory, and autoimmune diseases. In cancer, autophagy appears to play distinct roles depending on the context of the malignancy by either promoting or suppressing key determinants of cancer cell survival. This review covers recent developments in the understanding of autophagy and discusses potential therapeutic interventions that may alter the outcomes of certain diseases. View Full-Text
Keywords: autophagy; immunity; cancer; activators autophagy; immunity; cancer; activators
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Byun, S.; Lee, E.; Lee, K.W. Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer. Int. J. Mol. Sci. 2017, 18, 1959.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top