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Retinal Cell Degeneration in Animal Models

Medical Science Division, United Graduate School of Drug Discovery and Medical Information Sciences, Gifu 501-1194, Japan
Department of Tissue and Organ Development, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
Division of Animal Experiment, Life Science Research Center, Gifu University, Gifu 501-1194, Japan
Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
Department of Oral and Maxillofacial Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
Author to whom correspondence should be addressed.
Academic Editor: Katalin Prokai-Tatrai
Int. J. Mol. Sci. 2016, 17(1), 110;
Received: 23 October 2015 / Revised: 25 December 2015 / Accepted: 8 January 2016 / Published: 15 January 2016
(This article belongs to the Special Issue Neuroprotective Strategies 2015)
PDF [1207 KB, uploaded 15 January 2016]


The aim of this review is to provide an overview of various retinal cell degeneration models in animal induced by chemicals (N-methyl-d-aspartate- and CoCl2-induced), autoimmune (experimental autoimmune encephalomyelitis), mechanical stress (optic nerve crush-induced, light-induced) and ischemia (transient retinal ischemia-induced). The target regions, pathology and proposed mechanism of each model are described in a comparative fashion. Animal models of retinal cell degeneration provide insight into the underlying mechanisms of the disease, and will facilitate the development of novel effective therapeutic drugs to treat retinal cell damage. View Full-Text
Keywords: retinal cell degeneration; NMDA; CoCl2; EAE; ischemia; nerve crush; light-induced; animal model retinal cell degeneration; NMDA; CoCl2; EAE; ischemia; nerve crush; light-induced; animal model

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Niwa, M.; Aoki, H.; Hirata, A.; Tomita, H.; Green, P.G.; Hara, A. Retinal Cell Degeneration in Animal Models. Int. J. Mol. Sci. 2016, 17, 110.

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