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Open AccessArticle

New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix

1
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
2
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
3
Department of Pharmacy of Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813, Taiwan
4
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
5
Division of Surgical Oncology, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
6
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
7
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
8
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
9
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
10
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Vassilios Roussis and Efstathia Ioannou
Int. J. Mol. Sci. 2015, 16(9), 21950-21958; https://doi.org/10.3390/ijms160921950
Received: 7 August 2015 / Revised: 31 August 2015 / Accepted: 7 September 2015 / Published: 11 September 2015
(This article belongs to the Special Issue Bioactivity of Marine Natural Products)
Two new 24-homoscalarane sesterterpenoids, felixins F (1) and G (2), were isolated from the sponge Ircinia felix. The structures of new homoscalaranes 1 and 2 were elucidated by extensive spectroscopic methods, particularly with one-dimensional (1D) and two-dimensional (2D) NMR, and, by comparison, the spectral data with those of known analogues. The cytotoxicity of 1 and 2 against the proliferation of a limited panel of tumor cell lines was evaluated and 1 was found to show cytotoxicity toward the leukemia K562, MOLT-4, and SUP-T1 cells (IC50 ≤ 5.0 μM). View Full-Text
Keywords: Ircinia felix; sponge; homoscalarane; sesterterpenoid; cytotoxicity Ircinia felix; sponge; homoscalarane; sesterterpenoid; cytotoxicity
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MDPI and ACS Style

Lai, Y.-Y.; Chen, L.-C.; Wu, C.-F.; Lu, M.-C.; Wen, Z.-H.; Wu, T.-Y.; Fang, L.-S.; Wang, L.-H.; Wu, Y.-C.; Sung, P.-J. New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix. Int. J. Mol. Sci. 2015, 16, 21950-21958. https://doi.org/10.3390/ijms160921950

AMA Style

Lai Y-Y, Chen L-C, Wu C-F, Lu M-C, Wen Z-H, Wu T-Y, Fang L-S, Wang L-H, Wu Y-C, Sung P-J. New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix. International Journal of Molecular Sciences. 2015; 16(9):21950-21958. https://doi.org/10.3390/ijms160921950

Chicago/Turabian Style

Lai, Ya-Yuan; Chen, Li-Chai; Wu, Chug-Fung; Lu, Mei-Chin; Wen, Zhi-Hong; Wu, Tung-Ying; Fang, Lee-Shing; Wang, Li-Hsueh; Wu, Yang-Chang; Sung, Ping-Jyun. 2015. "New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix" Int. J. Mol. Sci. 16, no. 9: 21950-21958. https://doi.org/10.3390/ijms160921950

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