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Int. J. Mol. Sci. 2015, 16(9), 21950-21958;

New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix

Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
Department of Pharmacy of Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813, Taiwan
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Division of Surgical Oncology, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editors: Vassilios Roussis and Efstathia Ioannou
Received: 7 August 2015 / Revised: 31 August 2015 / Accepted: 7 September 2015 / Published: 11 September 2015
(This article belongs to the Special Issue Bioactivity of Marine Natural Products)
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Two new 24-homoscalarane sesterterpenoids, felixins F (1) and G (2), were isolated from the sponge Ircinia felix. The structures of new homoscalaranes 1 and 2 were elucidated by extensive spectroscopic methods, particularly with one-dimensional (1D) and two-dimensional (2D) NMR, and, by comparison, the spectral data with those of known analogues. The cytotoxicity of 1 and 2 against the proliferation of a limited panel of tumor cell lines was evaluated and 1 was found to show cytotoxicity toward the leukemia K562, MOLT-4, and SUP-T1 cells (IC50 ≤ 5.0 μM). View Full-Text
Keywords: Ircinia felix; sponge; homoscalarane; sesterterpenoid; cytotoxicity Ircinia felix; sponge; homoscalarane; sesterterpenoid; cytotoxicity

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Lai, Y.-Y.; Chen, L.-C.; Wu, C.-F.; Lu, M.-C.; Wen, Z.-H.; Wu, T.-Y.; Fang, L.-S.; Wang, L.-H.; Wu, Y.-C.; Sung, P.-J. New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix. Int. J. Mol. Sci. 2015, 16, 21950-21958.

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