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Open AccessArticle

Serial Changes of Serum Growth Factor Levels and Liver Regeneration after Partial Hepatectomy in Healthy Humans

1
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan
2
Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2013, 14(10), 20877-20889; https://doi.org/10.3390/ijms141020877
Received: 28 August 2013 / Revised: 8 October 2013 / Accepted: 14 October 2013 / Published: 17 October 2013
(This article belongs to the Collection Molecular Mechanisms of Human Liver Diseases)
This study aimed to investigate the associations of the serial changes of serum levels of various growth factors with liver regeneration after hepatectomy in healthy liver donors. Sixteen healthy liver donors who underwent conventional liver resection were included. Serum levels of various growth factors before hepatectomy and on postoperative day (POD) 1, 3, 5 and 7 were measured. Liver volume data calculated by multi-detector computed tomography using workstation. The ratio of remnant liver volume on POD 0 to liver volume before the operation was 51% ± 20%. The ratio of liver volume on POD 14 to liver volume on POD 0 were inversely correlated with remnant liver volume on POD 0 (r = −0.91). The ratio of liver volume on POD 14 to liver volume on POD 0 were significantly correlated with serum hepatocyte growth factor (HGF) levels on POD 1 (r = 0.54), serum leptin levels on POD 1 (r = 0.54), and serum macrophage colony-stimulating factor (M-CSF) levels on POD 5 (r = 0.76) and POD 7 (r = 0.80). These results suggest that early-phase elevation of serum levels of HGF, leptin and M-CSF may be associated with the acceleration of liver regeneration after hepatectomy in humans. View Full-Text
Keywords: hepatectomy; hepatocyte growth factor; human; leptin; liver regeneration; macrophage colony-stimulating factor hepatectomy; hepatocyte growth factor; human; leptin; liver regeneration; macrophage colony-stimulating factor
MDPI and ACS Style

Matsumoto, K.; Miyake, Y.; Umeda, Y.; Matsushita, H.; Matsuda, H.; Takaki, A.; Sadamori, H.; Nouso, K.; Yagi, T.; Fujiwara, T.; Yamamoto, K. Serial Changes of Serum Growth Factor Levels and Liver Regeneration after Partial Hepatectomy in Healthy Humans. Int. J. Mol. Sci. 2013, 14, 20877-20889. https://doi.org/10.3390/ijms141020877

AMA Style

Matsumoto K, Miyake Y, Umeda Y, Matsushita H, Matsuda H, Takaki A, Sadamori H, Nouso K, Yagi T, Fujiwara T, Yamamoto K. Serial Changes of Serum Growth Factor Levels and Liver Regeneration after Partial Hepatectomy in Healthy Humans. International Journal of Molecular Sciences. 2013; 14(10):20877-20889. https://doi.org/10.3390/ijms141020877

Chicago/Turabian Style

Matsumoto, Kazuyuki; Miyake, Yasuhiro; Umeda, Yuzo; Matsushita, Hiroshi; Matsuda, Hiroaki; Takaki, Akinobu; Sadamori, Hiroshi; Nouso, Kazuhiro; Yagi, Takahito; Fujiwara, Toshiyoshi; Yamamoto, Kazuhide. 2013. "Serial Changes of Serum Growth Factor Levels and Liver Regeneration after Partial Hepatectomy in Healthy Humans" Int. J. Mol. Sci. 14, no. 10: 20877-20889. https://doi.org/10.3390/ijms141020877

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