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Int. J. Mol. Sci. 2011, 12(8), 5039-5051;

Potential Antibacterial Activity of Carvacrol-Loaded Poly(DL-lactide-co-glycolide) (PLGA) Nanoparticles against Microbial Biofilm

Department of Drug Sciences, Faculty of Pharmacy, University G. d’Annunzio, Via dei Vestini 31, Chieti 66100, Italy
CeSI-Center for Research on Ageing & DNI-Department of Neuroscience and Imaging, University G. d’Annunzio, Chieti-Pescara, Via dei Vestini 31, Chieti 66100, Italy
Author to whom correspondence should be addressed.
Received: 30 May 2011 / Revised: 25 July 2011 / Accepted: 26 July 2011 / Published: 8 August 2011
(This article belongs to the Section Materials Science)
Full-Text   |   PDF [319 KB, uploaded 19 June 2014]


The ability to form biofilms contributes significantly to the pathogenesis of many microbial infections, including a variety of ocular diseases often associated with the biofilm formation on foreign materials. Carvacrol (Car.) is an important component of essential oils and recently has attracted much attention pursuant to its ability to promote microbial biofilm disruption. In the present study Car. has been encapsulated in poly(DL-lactide-co-glycolide (PLGA) nanocapsules in order to obtain a suitable drug delivery system that could represent a starting point for developing new therapeutic strategies against biofilm-associated infections, such as improving the drug effect by associating an antimicrobial agent with a biofilm viscoelasticity modifier. View Full-Text
Keywords: carvacrol; biofilm; PLGA nanoparticles carvacrol; biofilm; PLGA nanoparticles
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Iannitelli, A.; Grande, R.; Stefano, A.D.; Giulio, M.D.; Sozio, P.; Bessa, L.J.; Laserra, S.; Paolini, C.; Protasi, F.; Cellini, L. Potential Antibacterial Activity of Carvacrol-Loaded Poly(DL-lactide-co-glycolide) (PLGA) Nanoparticles against Microbial Biofilm. Int. J. Mol. Sci. 2011, 12, 5039-5051.

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