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Int. J. Mol. Sci. 2011, 12(7), 4395-4413;

Enabling Anticancer Therapeutics by Nanoparticle Carriers: The Delivery of Paclitaxel

School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
Author to whom correspondence should be addressed.
Received: 27 April 2011 / Revised: 9 June 2011 / Accepted: 15 June 2011 / Published: 7 July 2011
(This article belongs to the Special Issue Bioactive Nanoparticles (special issue))
Full-Text   |   PDF [468 KB, uploaded 19 June 2014]


Anticancer drugs, such as paclitaxel (PTX), are indispensable for the treatment of a variety of malignancies. However, the application of most drugs is greatly limited by the low water solubility, poor permeability, or high efflux from cells. Nanoparticles have been widely investigated to enable drug delivery due to their low toxicity, sustained drug release, molecular targeting, and additional therapeutic and imaging functions. This review takes paclitaxel as an example and compares different nanoparticle-based delivery systems for their effectiveness in cancer chemotherapy. View Full-Text
Keywords: nanomaterials; anticancer drugs; paclitaxel; drug carrier; drug delivery nanomaterials; anticancer drugs; paclitaxel; drug carrier; drug delivery
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Liu, Y.; Zhang, B.; Yan, B. Enabling Anticancer Therapeutics by Nanoparticle Carriers: The Delivery of Paclitaxel. Int. J. Mol. Sci. 2011, 12, 4395-4413.

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