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International Journal of Molecular Sciences, Volume 10, Issue 2

2009 February - 17 articles

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Articles (17)

  • Review
  • Open Access
117 Citations
17,285 Views
28 Pages

23 February 2009

A shift in glucose metabolism from oxidative phosphorylation to glycolysis is one of the biochemical hallmarks of tumor cells. Mitochondrial defects have been proposed to play an important role in the initiation and/or progression of various types of...

  • Review
  • Open Access
3 Citations
11,147 Views
21 Pages

23 February 2009

Reduced glycolytic and mitochondrial respiration rates are common features of apoptosis that may reflect key events contributing to cell death. However, it is unclear to what extent the rate changes can be explained by direct alterations in the kinet...

  • Review
  • Open Access
180 Citations
18,912 Views
10 Pages

20 February 2009

The large surface area and small size of nanoparticles provide properties and applications that are distinct from those of bulk materials. The ability of nanoparticles to influence protein folding and aggregation is interesting, not only because of t...

  • Review
  • Open Access
296 Citations
27,276 Views
18 Pages

Quantum Dots — Characterization, Preparation and Usage in Biological Systems

  • Jana Drbohlavova,
  • Vojtech Adam,
  • Rene Kizek and
  • Jaromir Hubalek

20 February 2009

The use of fluorescent nanoparticles as probes for bioanalytical applications is a highly promising technique because fluorescence-based techniques are very sensitive. Quantum dots (QDs) seem to show the greatest promise as labels for tagging and ima...

  • Article
  • Open Access
13 Citations
11,928 Views
17 Pages

19 February 2009

AcrAB-TolC is the major multidrug efflux system in Enterobacteriaceae recognizing structurally unrelated molecules including antibiotics, dyes, and detergents. Additionally, in Escherichia coli it mediates resistance to bile salts. In the plant patho...

  • Article
  • Open Access
5 Citations
12,385 Views
13 Pages

18 February 2009

A new approach for characterizing the intermediate of urea-denatured α-chymotrypsin (α-Chy) by hydrophobic interaction chromatography (HIC) is presented. The contact surface region (Z, S), affinity (logI), and the character of interaction force (j) o...

  • Review
  • Open Access
69 Citations
14,955 Views
17 Pages

13 February 2009

How the crowded environment inside cells affects folding, stability and structures of proteins is a vital question, since most proteins are made and function inside cells. Here we describe how crowded conditions can be created in vitro and in silico...

  • Review
  • Open Access
98 Citations
14,887 Views
27 Pages

Biodegradable Polydepsipeptides

  • Yakai Feng and
  • Jintang Guo

13 February 2009

This paper reviews the synthesis, characterization, biodegradation and usage of bioresorbable polymers based on polydepsipeptides. The ring-opening polymerization of morpholine-2,5-dione derivatives using organic Sn and enzyme lipase is discussed. Th...

  • Article
  • Open Access
5 Citations
13,483 Views
26 Pages

Selective Binding, Self-Assembly and Nanopatterning of the Creutz-Taube Ion on Surfaces

  • Yuliang Wang,
  • Marya Lieberman,
  • Qingling Hang and
  • Gary Bernstein

12 February 2009

The surface attachment properties of the Creutz-Taube ion, i.e., [(NH3)5Ru(pyrazine)Ru(NH3)5]5+, on both hydrophilic and hydrophobic types of surfaces were investigated using X-ray photoelectron spectroscopy (XPS). The results indicated that the Creu...

  • Article
  • Open Access
46 Citations
12,797 Views
13 Pages

Evaluation of Various Metallic Coatings on Steel to Mitigate Biofilm Formation

  • Hideyuki Kanematsu,
  • Hajime Ikigai and
  • Michiko Yoshitake

12 February 2009

In marine environments and water systems, it is easy for many structures to form biofilms on their surfaces and to be deteriorated due to the corrosion caused by biofilm formation by bacteria. The authors have investigated the antibacterial effects o...

  • Communication
  • Open Access
9 Citations
14,260 Views
11 Pages

5 February 2009

The sign preference of hydrogen bonded aqueous ionic clusters Χ±(H2O)i (n =1-5, Χ = F; Cl; Br) has been investigated using the Density Functional Theory and ab initio MP2 method. The present study indicates the anomalously large difference in formati...

  • Article
  • Open Access
234 Citations
18,598 Views
15 Pages

Biomass Production Potential of a Wastewater Alga Chlorella vulgaris ARC 1 under Elevated Levels of CO2 and Temperature

  • Senthil Chinnasamy,
  • Balasubramanian Ramakrishnan,
  • Ashish Bhatnagar and
  • Keshav C. Das

5 February 2009

The growth response of Chlorella vulgaris was studied under varying concentrations of carbon dioxide (ranging from 0.036 to 20%) and temperature (30, 40 and 50oC). The highest chlorophyll concentration (11 µg mL-1) and biomass (210 µg mL-1), which we...

  • Review
  • Open Access
473 Citations
43,291 Views
51 Pages

Quantum Dots for Live Cell and In Vivo Imaging

  • Maureen A. Walling,
  • Jennifer A. Novak and
  • Jason R. E. Shepard

3 February 2009

In the past few decades, technology has made immeasurable strides to enable visualization, identification, and quantitation in biological systems. Many of these technological advancements are occurring on the nanometer scale, where multiple scientifi...

  • Article
  • Open Access
10 Citations
11,971 Views
15 Pages

Expression of Mipu1 in Response to Myocardial Infarction in Rats

  • Guiliang Wang,
  • Xiaoxia Zuo,
  • Junwen Liu,
  • Lei Jiang,
  • Ying Liu,
  • Yazhu Zheng,
  • Bin Zhang and
  • Xianzhong Xiao

3 February 2009

Myocardial ischemic preconditioning up-regulated protein 1 (Mipu1) was cloned in our laboratory. Male Wistar rats were subjected to left anterior coronary artery ligation and sham-operation and sacrificed at 1 h, 3 h, 6 h, 12 h, 24 h, 3 d or 5 d afte...

  • Review
  • Open Access
130 Citations
37,643 Views
34 Pages

2 February 2009

Drosophila melanogaster has been utilized to model human brain diseases. In most of these invertebrate transgenic models, some aspects of human disease are reproduced. Although investigation of rodent models has been of significant impact, invertebra...

  • Article
  • Open Access
15 Citations
13,811 Views
12 Pages

Investigation on the Protective Effect of α-Mannan against the DNA Damage Induced by Aflatoxin B1 in Mouse Hepatocytes

  • Eduardo Madrigal-Santillán,
  • José Antonio Morales-González,
  • Manuel Sánchez-Gutiérrez,
  • Alicia Reyes-Arellano and
  • Eduardo Madrigal-Bujaidar

1 February 2009

Aflatoxin B1 is a contaminant of agricultural and dairy products that can be related to mutagenic and carcinogenic effects. In this report we explore the capacity of α-mannan (Man) to reduce the DNA damage induced by AFB1 in mouse hepatocytes. For th...

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Int. J. Mol. Sci. - ISSN 1422-0067