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Special Issue "Molecular System Bioenergetics"
Deadline for manuscript submissions: closed (31 January 2009).
Dr. Valdur Saks E-Mail
Laboratory of Bioenergetics, INSERM U884, Joseph Fourier University, Grenoble, France
Fax: +33 4 7651 4218
Interests: bioenergetics; systems biology; biophysics; enzymology; cell physiology
This Special Issue continues the series of publications on application of the new strategy of research – Systems Biology – in an important area of biological research: for investigation of the mechanisms of regulation of integrated processes of energy metabolism of cells. This series was started by publication by Wiley VCH, Weinheim, Germany in 2007 of the book Molecular System Bioenergetics. Energy for Life (http://www3.interscience.wiley.com/cgi-bin/bookhome/117349267).
Systems Biology is a new paradigm of biological sciences which opens wide perspectives of better understanding of complex biological processes at different levels, introducing network theories and new concepts such as that of system level properties not predictable from the studies of isolated components of the cells. Examples of these important system level properties are the phenomena of metabolic compartmentation and functional coupling depending on specific intracellular organization. This concept is also central for understanding the mechanisms of regulation of cellular energetics and other metabolic processes in the cells in vivo. In the current Specific Issue the authors describe and analyze wide variety of different aspects of the current state of the art in this important area, starting with description of philosophical and historical basis of systems biology approaches, network theories and their applications in biology and in particular in bioenergetics, compartmentation phenomena, intracellular interactions and mechanisms of signalling, important role of the cytoskeleton, in particular in the control of mitochondrial dynamics, arrangement, function and in modular organization of energy metabolism.
Valdur A. Saks
- systems biology
- molecular and cellular bioenergetics
- integrated energy metabolism
- intracellular signalling