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Open AccessArticle

Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides

Department of Chemistry, Faculty of Science, UAE University, Al-Ain P.O. Box 17551, UAE
Department of Biochemistry, Faculty of Medicine & Health Sciences, UAE University, Al-Ain P.O.Box 17666, UAE
Author to whom correspondence should be addressed.
Molecules 2004, 9(3), 109-116;
Received: 13 January 2004 / Accepted: 20 January 2004 / Published: 28 February 2004
(This article belongs to the Special Issue Biologically Relevant Heterocyclic Compounds)
2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for theirantitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM againstproliferation of the human promyelotic leukemia (HL60) cell line. View Full-Text
Keywords: Trifluoromethylpyrazole; glucopyranose; antitumor agents. Trifluoromethylpyrazole; glucopyranose; antitumor agents.
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Abdou, I.M.; Saleh, A.M.; Zohdi, H.F. Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides. Molecules 2004, 9, 109-116.

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