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Molecules 2001, 6(10), 815-824;

Synthesis, Antibacterial and Antifungal Activity of 4-Substituted-5-Aryl-1,2,4-Triazoles

Faculty of Technology and Metallurgy, The “Sv. Kiril & Metodij” University, R. Boskovic 16, 1000 Skopje, Macedonia
Faculty of Agriculture, Department of Microbiology, The “Sv. Kiril & Metodij” University, Bul. Aleksandar Makedonski, bb, 1000 Skopje, Macedonia
Institute of Chemistry, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 3, 21000 Novi Sad, Yugoslavia
Author to whom correspondence should be addressed.
Received: 8 February 2001 / Revised: 24 September 2001 / Accepted: 26 September 2001 / Published: 30 September 2001
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A few 4-allyl/amino-5-aryl-1,2,4-triazoles were synthesized and tested for antibacterial and antifungal effects against Escherichia coli, Bacillus subtilis, Salmonella enteritidis, Staphylococcus aureus, Aspergillus niger and Candida albicans. 4-Allyl-5-aryl-1,2,4-triazoles were obtained by the oxidative cyclization of the appropriate 1-substituted-4-allylthiosemicarbazides and 4-amino-5-aryl-1,2,4-triazoles were obtained by cyclization of the potassium salts of appropriately substituted dithiocarbazinic acids with hydrazine hydrate. The new synthesized compounds were characterized using IR, 1H- NMR, 13C-NMR and UV spectral data together with elemental analysis. View Full-Text
Keywords: Substituted benzoyl/phenylcetyl-4-allylthiosemicarbazides; 1; 2; 4-triazoles; cyclization; inhibition zone Substituted benzoyl/phenylcetyl-4-allylthiosemicarbazides; 1; 2; 4-triazoles; cyclization; inhibition zone

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Colanceska-Ragenovic, K.; Dimova, V.; Kakurinov, V.; Molnar, D.G.; Buzarovska, A. Synthesis, Antibacterial and Antifungal Activity of 4-Substituted-5-Aryl-1,2,4-Triazoles. Molecules 2001, 6, 815-824.

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