Next Article in Journal
Addition of Aromatic Nucleophiles to a C=N Double Bond of 1,2,5-Thiadiazole 1,1-Dioxide
Previous Article in Journal
Synthesis of 1,2,6-Thiadiazin 1,1-Dioxide Derivatives as Trypanocidal Agents
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 5
Issue 3
10.3390/50300501
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Abstract

Reactivity Studies of 5,6-Dimethyl- and 3,5,6-Trimethyl -1,2,4-Triazine–N4-Oxide Against Different Electrophiles

by
H. Cerecetto
,
M. González
,
P. Saenz
* and
G. Seoane
Cátedra de Química Orgánica, Facultad de Química, Universidad de la República General Flores 2124, Montevideo, Uruguay
*
Author to whom correspondence should be addressed.
Molecules 2000, 5(3), 501-502; https://doi.org/10.3390/50300501
Published: 22 March 2000
Versions Notes

Abstract

:
It describes the synthesis of new 1,2,6-Thiadiazin 1,1-dioxide derivatives using condensation of the Knoevenagel type. The products are evaluated in vitro as trypanocidal agents.

Introduction

We have previously reported the synthesis of three series of new compounds and the biological evaluation against Trypanosoma cruzi of 1,2,6-Thiadiazin 1,1-dioxide derivatives, structurally related to Nifurtimox [1,2]. The in vitro assay showed that some of them exhibit significant activity against epimastigote forms of T. cruzi, but the cytotoxicity of this type of compounds against Vero cells was highest than the reference drug.

Experimental

In this work we design new structures, changing the free radical generator. Molecules 05 00501 i001
All the compounds were prepared according to the following synthetic pathway Molecules 05 00501 i002

Results and Discussion

All the compounds have been obtained with good yields, and have been characterized by IR, 1H-NMR, 13C-NMR and MS.
All the products were tested in vitro against T. cruzi epimastigote forms and that more promising were tested their cytotoxicity.

Acknowledgements 

The authors thank CYTED (Ciencia y Tecnología para el desarrollo) and RELAQ (Red Latinoamericana de Ciencia Química).

References and Notes

  1. Synthesis and antichagasic properties of new 1,2,6-Thiadiazin-3,5-dione 1,1-dioxides, XVth INTERNATIONAL SYMPOSIUM ON MEDICINAL CHEMISTRY, 6 al 10 de setiembre de 1998, Edimburgo.
  2. Synthesis and antichagasic properties of new 1,2,6-Thiadiazin-3,5-dione 1,1-dioxides and related compounds. Arzneimittel Ferschung. (in press).

Share and Cite

MDPI and ACS Style

Cerecetto, H.; González, M.; Saenz, P.; Seoane, G. Reactivity Studies of 5,6-Dimethyl- and 3,5,6-Trimethyl -1,2,4-Triazine–N4-Oxide Against Different Electrophiles. Molecules 2000, 5, 501-502. https://doi.org/10.3390/50300501

AMA Style

Cerecetto H, González M, Saenz P, Seoane G. Reactivity Studies of 5,6-Dimethyl- and 3,5,6-Trimethyl -1,2,4-Triazine–N4-Oxide Against Different Electrophiles. Molecules. 2000; 5(3):501-502. https://doi.org/10.3390/50300501

Chicago/Turabian Style

Cerecetto, H., M. González, P. Saenz, and G. Seoane. 2000. "Reactivity Studies of 5,6-Dimethyl- and 3,5,6-Trimethyl -1,2,4-Triazine–N4-Oxide Against Different Electrophiles" Molecules 5, no. 3: 501-502. https://doi.org/10.3390/50300501

APA Style

Cerecetto, H., González, M., Saenz, P., & Seoane, G. (2000). Reactivity Studies of 5,6-Dimethyl- and 3,5,6-Trimethyl -1,2,4-Triazine–N4-Oxide Against Different Electrophiles. Molecules, 5(3), 501-502. https://doi.org/10.3390/50300501

Article Metrics

Back to TopTop