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Molecules, Volume 26, Issue 8

April-2 2021 - 296 articles

Cover Story: Current therapies for bone metastases, targeting bone remodeling, are mainly palliative. Aside from these treatments, systemic radiation has also been used to target every bone metastatic lesion. Bone seeking beta minus particle-emitting radiopharmaceuticals have shown pain relief, but they have failed to extend overall survival of patients with bone metastases. However, recent clinical trials indicate that radium-223 dichloride, an alpha particle-emitting radiopharmaceutical, improves the overall survival of bone metastatic prostate cancer patients. This success has renewed interest in targeted alpha particle therapy development for bone metastasis, and current data suggest that targeted alpha particle therapies hold promise in improving clinical outcomes in cancer patients with bone metastases. View this paper.
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Articles (296)

  • Article
  • Open Access
5 Citations
3,472 Views
10 Pages

20 April 2021

The idea of popularity/abundance of chemical compounds is widely used in non-target chemical analysis involving environmental studies. To have a clear quantitative basis for this idea, frequency distributions of chemical compounds over indicators of...

  • Article
  • Open Access
6 Citations
4,247 Views
15 Pages

20 April 2021

Australian sweet lupin, the largest legume crop grown in Western Australia, is receiving global attention from the producers of new foods. To understand the effect of protein on cheese yield, lupin milk proteins were separated from the first, second,...

  • Article
  • Open Access
15 Citations
3,674 Views
26 Pages

Physicochemical and Adsorption Characteristics of Divinylbenzene-co-Triethoxyvinylsilane Microspheres as Materials for the Removal of Organic Compounds

  • Alicja Bosacka,
  • Małgorzata Zienkiewicz-Strzalka,
  • Małgorzata Wasilewska,
  • Anna Derylo-Marczewska and
  • Beata Podkościelna

20 April 2021

In this work, organic-inorganic materials with spherical shape consisting of divinylbenzene (DVB) and triethoxyvinylsilane (TEVS) were synthesized and investigated by different complementary techniques. The obtained microspheres may be applied as sor...

  • Article
  • Open Access
6 Citations
3,837 Views
9 Pages

20 April 2021

In this study, microcapsules were prepared by solvent evaporation technique using ethyl cellulose component as wall and essential oil as core material. The synthesis of microcapsules was carried out using different oil masses. The analysis of the mic...

  • Article
  • Open Access
23 Citations
3,658 Views
16 Pages

Proteomic and Bioinformatic Investigation of Altered Pathways in Neuroglobin-Deficient Breast Cancer Cells

  • Michele Costanzo,
  • Marco Fiocchetti,
  • Paolo Ascenzi,
  • Maria Marino,
  • Marianna Caterino and
  • Margherita Ruoppolo

20 April 2021

Neuroglobin (NGB) is a myoglobin-like monomeric globin that is involved in several processes, displaying a pivotal redox-dependent protective role in neuronal and extra-neuronal cells. NGB remarkably exerts its function upon upregulation by NGB induc...

  • Article
  • Open Access
15 Citations
5,056 Views
18 Pages

20 April 2021

Fibromyalgia is a disease characterized by lowered pain threshold, mood disorders, and decreased muscular strength. It results from a complex dysfunction of the nervous system and due to unknown etiology, its diagnosis, treatment, and prevention are...

  • Article
  • Open Access
8 Citations
3,596 Views
12 Pages

The Interaction of Human Glutathione Transferase GSTA1-1 with Reactive Dyes

  • Mohammed Hamed Alqarni,
  • Ahmed Ibrahim Foudah,
  • Magdy Mohamed Muharram and
  • Nikolaos E. Labrou

20 April 2021

Human glutathione transferase A1-1 (hGSTA1-1) contributes to developing resistance to anticancer drugs and, therefore, is promising in terms of drug-design targets for coping with this phenomenon. In the present study, the interaction of anthraquinon...

  • Article
  • Open Access
18 Citations
3,892 Views
18 Pages

20 April 2021

Radix Astragali is referred to as a variety of food-medicine herb, and it is commonly applied as Traditional Chinese Medicine (TCM). However, it is extremely difficult to extract its bio-active compounds (astragaloside IV) and apply it in food proces...

  • Article
  • Open Access
6 Citations
2,634 Views
19 Pages

19 April 2021

We optimized the hot water extraction of polysaccharides from the root of Henry wood betony (RHWPs) using a uniform test and explored their anti-tumor activities in vitro and in vivo. The optimal extraction conditions were as follows: 40 min extracti...

  • Article
  • Open Access
11 Citations
2,976 Views
13 Pages

Role of pH on Nanostructured SERS Active Substrates for Detection of Organic Dyes

  • Viviana Mollica Nardo,
  • Vincenzo Renda,
  • Sebastiano Trusso and
  • Rosina Celeste Ponterio

19 April 2021

Surface Enhanced Raman Spectroscopy is commonly used as analytical improvement to conventional Raman spectroscopy, able to respond to qualitative diagnostic enquiries, which involve low-concentrated molecular species in complex matrix. In this paper,...

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Molecules - ISSN 1420-3049