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Prenyleudesmanes and A Hexanorlanostane from the Roots of Lonicera macranthoides

by Hui Lyu 1,2,†, Wenjuan Liu 3,†, Bai Bai 1, Yu Shan 1, Christian Paetz 2, Xu Feng 1,* and Yu Chen 1,*
1
Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, The Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210000, China
2
Max Planck Institute for Chemical Ecology, D-07745 Jena, Germany
3
Naval Compound Community Health Care Station, Beijing 100853, China
*
Authors to whom correspondence should be addressed.
These two authors contributed equally to this work.
Molecules 2019, 24(23), 4276; https://doi.org/10.3390/molecules24234276
Received: 22 October 2019 / Revised: 16 November 2019 / Accepted: 21 November 2019 / Published: 23 November 2019
(This article belongs to the Special Issue Terpenes and Terpene Derivatives)
Three previously undescribed compounds, two prenyleudesmanes (1 and 2), and one hexanorlanostane (3), were isolated from the roots of Lonicera macranthoides. Their structures were established based on 1D and 2D nuclear magnetic resonance (NMR) spectra and high-resolution electrospray ionization mass spectral (HR-ESI-MS) data. The absolute configurations of 1 and 3 were determined by X-ray diffraction. To the best of our knowledge, this is the first time that the absolute configuration of a prenyleudesmane with a trans-decalin system and a hexanorlanostane have been unambiguously confirmed by single-crystal X-ray diffraction with Cu Kα radiation. Thecompounds were tested for their antiproliferative activity on the cancer cell lines (HepG2 and HeLa). The compounds 13 exhibited moderate inhibitory effects against two human cancer cell lines. View Full-Text
Keywords: Lonicera macranthoides; Caprifoliaceae; Prenyleudesmanes; Hexanortriterpenes; Antiproliferative Lonicera macranthoides; Caprifoliaceae; Prenyleudesmanes; Hexanortriterpenes; Antiproliferative
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Lyu, H.; Liu, W.; Bai, B.; Shan, Y.; Paetz, C.; Feng, X.; Chen, Y. Prenyleudesmanes and A Hexanorlanostane from the Roots of Lonicera macranthoides. Molecules 2019, 24, 4276.

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