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Open AccessReview

Structural Diversity and Biological Activities of Novel Secondary Metabolites from Endophytes

by Han Gao 1,†, Gang Li 1,† and Hong-Xiang Lou 1,2,*
Department of Natural Medicine and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266021, China
Department of Natural Product Chemistry, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2018, 23(3), 646;
Received: 23 February 2018 / Revised: 10 March 2018 / Accepted: 11 March 2018 / Published: 13 March 2018
(This article belongs to the Collection Bioactive Compounds)
Exploration of structurally novel natural products greatly facilitates the discovery of biologically active pharmacophores that are biologically validated starting points for the development of new drugs. Endophytes that colonize the internal tissues of plant species, have been proven to produce a large number of structurally diverse secondary metabolites. These molecules exhibit remarkable biological activities, including antimicrobial, anticancer, anti-inflammatory and antiviral properties, to name but a few. This review surveys the structurally diverse natural products with new carbon skeletons, unusual ring systems, or rare structural moieties that have been isolated from endophytes between 1996 and 2016. It covers their structures and bioactivities. Biosynthesis and/or total syntheses of some important compounds are also highlighted. Some novel secondary metabolites with marked biological activities might deserve more attention from chemists and biologists in further studies. View Full-Text
Keywords: endophytes; natural products; skeletons; biosynthesis; bioactivities endophytes; natural products; skeletons; biosynthesis; bioactivities
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MDPI and ACS Style

Gao, H.; Li, G.; Lou, H.-X. Structural Diversity and Biological Activities of Novel Secondary Metabolites from Endophytes. Molecules 2018, 23, 646.

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