Next Article in Journal
Structural Diversity and Biological Activities of Novel Secondary Metabolites from Endophytes
Previous Article in Journal
The Effect of Tomatine on Gene Expression and Cell Monolayer Integrity in Caco-2
Article

Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans

1
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Via Consolare Valeria, 98123 Messina, Italy
2
Department of Human Pathology of Adult and Childhood “Gaetano Barresi”, University of Messina, Via Consolare Valeria, 98123 Messina, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this study.
Molecules 2018, 23(3), 645; https://doi.org/10.3390/molecules23030645
Received: 30 January 2018 / Revised: 3 March 2018 / Accepted: 11 March 2018 / Published: 13 March 2018
(This article belongs to the Section Medicinal Chemistry)
Balanitis xerotica obliterans (BXO) is a chronic inflammatory skin disorder, considered the male genital variant of lichen sclerosus. Anti-inflammatory drugs are commonly used in BXO. We evaluated the effects of an innovative formulation of ozonated olive oil with vitamin E acetate (OZOILE®) on the inflammatory status and tissue remodeling in male children with BXO. The mRNA transcripts of proteins involved either in inflammation or in dynamics of tissue regeneration were analyzed by quantitative real-time PCR, in foreskins affected by BXO removed from patients untreated or treated with OZOILE® cream for 7 days before circumcision. We found a significant reduction in mRNA levels of IL-1β, TNF-α, INF–γ, transglutaminase 2 and NOS2 in foreskins treated with OZOILE® in comparison to untreated ones (p < 0.001). No significant differences were observed in NF-κB activation in the specimens obtained from treated and untreated patients. Hence, OZOILE® treatment up-regulated hypoxia-inducible factor (HIF)-1alpha, vascular endothelial growth factor (VEGF) and E-cadherin gene expression (p < 0.001). The treatment with OZOILE® showed effective results in children affected by BXO by reducing the inflammatory process and stimulating mechanisms for tissue regeneration of the foreskin. A randomized clinical trial on a large number of children affected by BXO might be useful to verify the efficacy of topical treatment with OZOILE®. View Full-Text
Keywords: balanitis xerotica obliterans; antioxidant therapy; ozonated olive oil; vitamin E acetate; inflammation; tissue regeneration; HIF-1 alpha balanitis xerotica obliterans; antioxidant therapy; ozonated olive oil; vitamin E acetate; inflammation; tissue regeneration; HIF-1 alpha
Show Figures

Graphical abstract

MDPI and ACS Style

Currò, M.; Russo, T.; Ferlazzo, N.; Caccamo, D.; Antonuccio, P.; Arena, S.; Parisi, S.; Perrone, P.; Ientile, R.; Romeo, C.; Impellizzeri, P. Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans. Molecules 2018, 23, 645. https://doi.org/10.3390/molecules23030645

AMA Style

Currò M, Russo T, Ferlazzo N, Caccamo D, Antonuccio P, Arena S, Parisi S, Perrone P, Ientile R, Romeo C, Impellizzeri P. Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans. Molecules. 2018; 23(3):645. https://doi.org/10.3390/molecules23030645

Chicago/Turabian Style

Currò, Monica, Tiziana Russo, Nadia Ferlazzo, Daniela Caccamo, Pietro Antonuccio, Salvatore Arena, Saveria Parisi, Patrizia Perrone, Riccardo Ientile, Carmelo Romeo, and Pietro Impellizzeri. 2018. "Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans" Molecules 23, no. 3: 645. https://doi.org/10.3390/molecules23030645

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop