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  • Review
  • Open Access
11 Citations
3,766 Views
19 Pages

In-Depth Understanding of Ecklonia stolonifera Okamura: A Review of Its Bioactivities and Bioactive Compounds

  • Xiao Men,
  • Xionggao Han,
  • Se-Jeong Lee,
  • Geon Oh,
  • Heegu Jin,
  • Hyun-Ji Oh,
  • Eunjin Kim,
  • Jongwook Kim,
  • Boo-Yong Lee and
  • Ok-Hwan Lee
  • + 1 author

27 September 2022

Ecklonia stolonifera Okamura (ES) is mainly distributed in the coastal areas of the middle Pacific, around Korea and Japan, and has a long-standing edible value. It is rich in various compounds, such as polysaccharides, fatty acids, alginic acid, fuc...

  • Review
  • Open Access
155 Citations
16,746 Views
27 Pages

Bioactivities and Health Benefits of Wild Fruits

  • Ya Li,
  • Jiao-Jiao Zhang,
  • Dong-Ping Xu,
  • Tong Zhou,
  • Yue Zhou,
  • Sha Li and
  • Hua-Bin Li

Wild fruits are exotic or underutilized. Wild fruits contain many bioactive compounds, such as anthocyanins and flavonoids. Many studies have shown that wild fruits possess various bioactivities and health benefits, such as free radical scavenging, a...

  • Review
  • Open Access
366 Citations
21,757 Views
38 Pages

Marine Peptides: Bioactivities and Applications

  • Randy Chi Fai Cheung,
  • Tzi Bun Ng and
  • Jack Ho Wong

29 June 2015

Peptides are important bioactive natural products which are present in many marine species. These marine peptides have high potential nutraceutical and medicinal values because of their broad spectra of bioactivities. Their antimicrobial, antiviral,...

  • Review
  • Open Access
303 Citations
73,185 Views
64 Pages

Dietary Sources and Bioactivities of Melatonin

  • Xiao Meng,
  • Ya Li,
  • Sha Li,
  • Yue Zhou,
  • Ren-You Gan,
  • Dong-Ping Xu and
  • Hua-Bin Li

7 April 2017

Insomnia is a serious worldwide health threat, affecting nearly one third of the general population. Melatonin has been reported to improve sleep efficiency and it was found that eating melatonin-rich foods could assist sleep. During the last decades...

  • Review
  • Open Access
246 Citations
15,800 Views
20 Pages

Bromophenols in Marine Algae and Their Bioactivities

  • Ming Liu,
  • Poul Erik Hansen and
  • Xiukun Lin

22 July 2011

Marine algae contain various bromophenols that have been shown to possess a variety of biological activities, including antioxidant, antimicrobial, anticancer, anti-diabetic, and anti-thrombotic effects. Here, we briefly review the recent progress of...

  • Review
  • Open Access
44 Citations
8,180 Views
33 Pages

The Preparation and Potential Bioactivities of Modified Pectins: A Review

  • Xu Jiao,
  • Fei Li,
  • Jing Zhao,
  • Yunlu Wei,
  • Luyao Zhang,
  • Wenjun Yu and
  • Quanhong Li

27 February 2023

Pectins are complex polysaccharides that are widely found in plant cells and have a variety of bioactivities. However, the high molecular weights (Mw) and complex structures of natural pectins mean that they are difficult for organisms to absorb and...

  • Review
  • Open Access
23 Citations
7,315 Views
20 Pages

Phytochemistry, Bioactivities and Traditional Uses of Michelia × alba

  • Kian-Kai Cheng,
  • Muhammad Helmi Nadri,
  • Nor Zalina Othman,
  • Siti Nor Azlina Abd Rashid,
  • Ying-Chin Lim and
  • Hong-Yeng Leong

Michelia × alba (M. alba) is a flowering tree best known for its essential oil, which has long been used as a fragrance ingredient for perfume and cosmetics. In addition, the plant has been used in traditional medicine in Asia and dates back hu...

  • Feature Paper
  • Review
  • Open Access
20 Citations
12,245 Views
24 Pages

Bioactivities of Kenaf Biomass Extracts: A Review

  • Danial ‘Aizat Norhisham,
  • Norsharina Md Saad,
  • Siti Rokhiyah Ahmad Usuldin,
  • Diwiyaa A G Vayabari,
  • Zul Ilham,
  • Mohamad Faizal Ibrahim and
  • Wan Abd Al Qadr Imad Wan-Mohtar

11 April 2023

Kenaf or Hibiscus cannabinus is an annual herbaceous crop that grows well in temperate regions with high rainfall and abundant solar radiation. This Malvaceae member is famously known for its high-quality fibre that is directly retrieved from its dri...

  • Review
  • Open Access
66 Citations
9,694 Views
31 Pages

Ruta Essential Oils: Composition and Bioactivities

  • Lutfun Nahar,
  • Hesham R. El-Seedi,
  • Shaden A. M. Khalifa,
  • Majid Mohammadhosseini and
  • Satyajit D. Sarker

6 August 2021

Ruta L. is a typical genus of the citrus family, Rutaceae Juss. and comprises ca. 40 different species, mainly distributed in the Mediterranean region. Ruta species have long been used in traditional medicines as an abortifacient and emmenagogue and...

  • Review
  • Open Access
136 Citations
23,385 Views
16 Pages

Bioactivities and Health Benefits of Mushrooms Mainly from China

  • Jiao-Jiao Zhang,
  • Ya Li,
  • Tong Zhou,
  • Dong-Ping Xu,
  • Pei Zhang,
  • Sha Li and
  • Hua-Bin Li

Many mushrooms have been used as foods and medicines for a long time. Mushrooms contain polyphenols, polysaccharides, vitamins and minerals. Studies show that mushrooms possess various bioactivities, such as antioxidant, anti-inflammatory, anticancer...

  • Review
  • Open Access
26 Citations
7,597 Views
24 Pages

30 July 2021

The present review comprehensively gathered phytochemical, bioactivity, and pharmacokinetic reports on a linear furanocoumarin, namely oxypeucedanin. Oxypeucedanin (OP), which structurally contains an epoxide ring, has been majorly isolated from ethy...

  • Review
  • Open Access
59 Citations
8,313 Views
22 Pages

Endophytic Fungal Terpenoids: Natural Role and Bioactivities

  • Juan M. Galindo-Solís and
  • Francisco J. Fernández

Endophytic fungi are a highly diverse group of fungi that intermittently colonize all plants without causing symptoms of the disease. They sense and respond to physiological and environmental changes of their host plant and microbiome. The inter-orga...

  • Review
  • Open Access
23 Citations
5,005 Views
18 Pages

Advances in Extraction Protocols, Degradation Methods, and Bioactivities of Proanthocyanidins

  • Lishan Liang,
  • Yingjie Liu,
  • Liyan Wu,
  • Luo Weng,
  • Honghao Qiu,
  • Wenting Zhong and
  • Fanxin Meng

Proanthocyanidins, natural polyphenolic compounds abundantly present in plants, exhibit diverse bioactivities, including antioxidative, anti-inflammatory, and antibacterial effects. These bioactivities are intricately linked to the degree of polymeri...

  • Review
  • Open Access
29 Citations
5,494 Views
21 Pages

Sulfated Galactofucans: An Outstanding Class of Fucoidans with Promising Bioactivities

  • Ahmed Zayed,
  • Jose Avila-Peltroche,
  • Mona El-Aasr and
  • Roland Ulber

24 June 2022

Fucoidans encompass versatile and heterogeneous sulfated biopolysaccharides of marine origin, specifically brown algae and marine invertebrates. Their chemistry and bioactivities have been extensively investigated in the last few decades. The reporte...

  • Review
  • Open Access
26 Citations
6,628 Views
52 Pages

21 November 2022

Pestalotiopsis species have gained attention thanks to their structurally complex and biologically active secondary metabolites. In past decades, several new secondary metabolites were isolated and identified. Their bioactivities were tested, includi...

  • Review
  • Open Access
396 Citations
14,049 Views
16 Pages

Phenolics, which are secondary metabolites of plants, exhibit remarkable bioactivities. In this contribution, we have focused on their protective effect against chronic diseases rather than their antioxidant activities, which have been widely discuss...

  • Review
  • Open Access
25 Citations
7,467 Views
20 Pages

Metabolites and Their Bioactivities from the Genus Cordyceps

  • Shuai-Ling Qu,
  • Su-Su Li,
  • Dong Li and
  • Pei-Ji Zhao

The Cordyceps genus is a group of ascomycete parasitic fungi, and all known species of this genus are endoparasites; they mainly feed on insects or arthropods and a few feed on other fungi. Fungi of this genus have evolved highly specific and complex...

  • Review
  • Open Access
47 Citations
8,078 Views
51 Pages

Marine Indole Alkaloids—Isolation, Structure and Bioactivities

  • Yong Hu,
  • Siling Chen,
  • Fang Yang and
  • Shuai Dong

24 November 2021

Indole alkaloids are heterocyclic natural products with extensive pharmacological activities. As an important source of lead compounds, many clinical drugs have been derived from natural indole compounds. Marine indole alkaloids, from unique marine e...

  • Review
  • Open Access
2 Citations
3,120 Views
31 Pages

A Comprehensive Review on Chemical Structures and Bioactivities of Ostropomycetidae Lichens

  • Yunhui Wang,
  • Chengyue Hao,
  • Shuhao Jiang,
  • Yanhu Ju,
  • Wei Li and
  • Zefeng Jia

9 May 2025

Lichenized fungi, recognized as an ecologically vital and pharmaceutically promising resource, hold substantial value in both environmental conservation and medicinal applications. As the second largest subclass within the lichen-forming fungi of Lec...

  • Review
  • Open Access
3 Citations
1,903 Views
24 Pages

Isolation, Structures, and Bioactivities of Polysaccharides from Achyranthes bidentata: A Review

  • Lin Li,
  • Zhihong Wang,
  • Wei Zhang,
  • Longxin Chen,
  • Yingying Yang,
  • Wan Yang,
  • Mengkun Li,
  • Chunhuan Yuan,
  • Limeng Zhang and
  • Linqing Wang

Achyranthes bidentata, a traditional Chinese medicinal herb, has garnered significant attentions due to its diverse bioactivities and substantial market potential. Recent advancements in phytochemical and pharmacological research have identified poly...

  • Review
  • Open Access
4 Citations
1,677 Views
13 Pages

Indolizidines have long been recognized for their valuable bioactivities, their common feature being a bicyclic structure connected via a nitrogen atom. Traditionally, plants have been identified as the primary producers. However, recent discoveries...

  • Review
  • Open Access
5 Citations
3,009 Views
28 Pages

Genus Smenospongia: Untapped Treasure of Biometabolites—Biosynthesis, Synthesis, and Bioactivities

  • Sabrin R. M. Ibrahim,
  • Sana A. Fadil,
  • Haifa A. Fadil,
  • Rawan H. Hareeri,
  • Hossam M. Abdallah and
  • Gamal A. Mohamed

14 September 2022

Marine sponges continue to attract remarkable attention as one of the richest pools of bioactive metabolites in the marine environment. The genus Smenospongia (order Dictyoceratida, family Thorectidae) sponges can produce diverse classes of metabolit...

  • Review
  • Open Access
2 Citations
1,652 Views
22 Pages

Bioactivities Derived from Dry-Cured Ham Peptides: A Review

  • Noelia Hernández Correas,
  • Andrea M. Liceaga,
  • Adela Abellán,
  • Beatriz Muñoz-Rosique and
  • Luis Tejada

18 August 2025

Dry-cured ham is a traditional food in the Mediterranean diet, which, in addition to its sensory qualities, is a natural source of bioactive peptides generated during the curing process through the action of endogenous enzymes on muscle and sarcoplas...

  • Review
  • Open Access
38 Citations
5,382 Views
18 Pages

1 November 2020

Paecilomyces, a common saprobic filamentous fungus, not only plays an important role in biological control, but also has applications in medicine, food, and environmental protection. In this paper, 223 secondary metabolites and their bioactivities fr...

  • Review
  • Open Access
29 Citations
5,230 Views
46 Pages

Aspergillus ochraceus: Metabolites, Bioactivities, Biosynthesis, and Biotechnological Potential

  • Rawan H. Hareeri,
  • Mohammed M. Aldurdunji,
  • Hossam M. Abdallah,
  • Ali A. Alqarni,
  • Shaimaa G. A. Mohamed,
  • Gamal A. Mohamed and
  • Sabrin R. M. Ibrahim

10 October 2022

Fungus continues to attract great attention as a promising pool of biometabolites. Aspergillus ochraceus Wilh (Aspergillaceae) has established its capacity to biosynthesize a myriad of metabolites belonging to different chemical classes, such as isoc...

  • Article
  • Open Access
67 Citations
6,677 Views
12 Pages

Benzopyranones from the Endophytic Fungus Hyalodendriella sp. Ponipodef12 and Their Bioactivities

  • Xiangjie Meng,
  • Ziling Mao,
  • Jingfeng Lou,
  • Liang Xu,
  • Lingyun Zhong,
  • Youliang Peng,
  • Ligang Zhou and
  • Mingan Wang

25 September 2012

The endophytic fungus Hyalodendriella sp. Ponipodef12 was isolated from the hybrid ‘Neva’ of Populus deltoides Marsh × P. nigra L. In this study, four benzopyranones were isolated from the ethyl acetate extract of Hyalodendriella sp. Ponipodef12, and...

  • Review
  • Open Access
19 Citations
4,548 Views
40 Pages

Unveiling Drimenol: A Phytochemical with Multifaceted Bioactivities

  • Zhongming Yang,
  • Kim Wei Chan,
  • Md Zuki Abu Bakar and
  • Xi Deng

5 September 2024

Drimenol, a phytochemical with a distinct odor is found in edible aromatic plants, such as Polygonum minus (known as kesum in Malaysia) and Drimys winteri. Recently, drimenol has received increasing attention owing to its diverse biological activitie...

  • Review
  • Open Access
38 Citations
5,410 Views
16 Pages

23 June 2020

Macrocyclic trichothecenes are an important group of trichothecenes bearing a large ring. Despite the fact that many of trichothecenes are of concern in agriculture, food contamination, health care and building protection, the macrocyclic ones are be...

  • Review
  • Open Access
15 Citations
3,322 Views
20 Pages

Marine-Derived Xanthone from 2010 to 2021: Isolation, Bioactivities and Total Synthesis

  • Ana C. S. Veríssimo,
  • Diana C. G. A. Pinto and
  • Artur M. S. Silva

25 May 2022

Marine life has proved to be an invaluable source of new compounds with significant bioactivities, such as xanthones. This review summarizes the advances made in the study of marine-derived xanthones from 2010 to 2021, from isolation towards synthesi...

  • Review
  • Open Access
24 Citations
4,856 Views
20 Pages

Glucomannan in Dendrobium catenatum: Bioactivities, Biosynthesis and Perspective

  • Luyan Qi,
  • Yan Shi,
  • Cong Li,
  • Jingjing Liu,
  • Sun-Li Chong,
  • Kean-Jin Lim,
  • Jinping Si,
  • Zhigang Han and
  • Donghong Chen

27 October 2022

Dendrobium catenatum is a classical and precious dual-use plant for both medicine and food in China. It was first recorded in Shen Nong’s Herbal Classic, and has the traditional functions of nourishing yin, antipyresis, tonifying the stomach, a...

  • Article
  • Open Access
12 Citations
2,648 Views
16 Pages

An Acidic Heteropolysaccharide Isolated from Pueraria lobata and Its Bioactivities

  • Shifan Zhao,
  • Hualei Xue,
  • Yijiong Tao,
  • Kai Chen,
  • Xiao Li and
  • Mi Wang

A novel water-soluble acidic heteropolysaccharide, called PPL-1, was purified from Pueraria lobata. PPL-1 had an average molecular weight of 35 Kad, and it was composed of glucose, arabinose, galactose and galacturonic acid (6.3:0.8:0.8:2.1). In acco...

  • Review
  • Open Access
8 Citations
3,215 Views
31 Pages

Non-Bovine Milk as Functional Foods with Focus on Their Antioxidant and Anti-Inflammatory Bioactivities

  • Yan Li,
  • Qingshan Ma,
  • Mengmeng Li,
  • Wenqiang Liu,
  • Yihong Liu,
  • Menghan Wang,
  • Changfa Wang and
  • Muhammad Zahoor Khan

The growing interest in functional foods has directed scientific attention toward alternative milk sources, particularly camel and donkey milk, which have been traditionally consumed for their purported health benefits across diverse cultures. These...

  • Review
  • Open Access
284 Citations
18,983 Views
26 Pages

Natural Sources and Bioactivities of 2,4-Di-Tert-Butylphenol and Its Analogs

  • Fuqiang Zhao,
  • Ping Wang,
  • Rima D. Lucardi,
  • Zushang Su and
  • Shiyou Li

6 January 2020

2,4-Di-tert-butylphenol or 2,4-bis(1,1-dimethylethyl)-phenol (2,4-DTBP) is a common toxic secondary metabolite produced by various groups of organisms. The biosources and bioactivities of 2,4-DTBP have been well investigated, but the phenol has not b...

  • Review
  • Open Access
69 Citations
8,224 Views
14 Pages

7 February 2023

Polysaccharides are important components of higher plants and have attracted increasing attention due to their many nutraceutical benefits in humans. Fructans, heterogeneous fructose polymers that serve as storage carbohydrates in various plants, rep...

  • Review
  • Open Access
11 Citations
3,605 Views
19 Pages

Recent Advances in Chemistry and Bioactivities of Secondary Metabolites from the Genus Acremonium

  • Yuning Qin,
  • Humu Lu,
  • Xin Qi,
  • Miaoping Lin,
  • Chenghai Gao,
  • Yonghong Liu and
  • Xiaowei Luo

3 January 2024

Acremonium fungi is one of the greatest and most complex genera in Hyphomycetes, comprising 130 species of marine and terrestrial sources. The past decades have witnessed substantial chemical and biological investigations on the diverse secondary met...

  • Article
  • Open Access
28 Citations
5,998 Views
20 Pages

Chemical Profile and Bioactivities of Extracts from Edible Plants Readily Available in Portugal

  • Beatriz Nunes Silva,
  • Vasco Cadavez,
  • Pedro Ferreira-Santos,
  • Maria José Alves,
  • Isabel C. F. R. Ferreira,
  • Lillian Barros,
  • José António Teixeira and
  • Ursula Gonzales-Barron

22 March 2021

Plant extracts have been proposed as alternative biocides and antioxidants to be included in a variety of food products. In this work, to assess the potential of French lavender, lemon balm, basil, tarragon, sage, and spearmint to be used as food add...

  • Review
  • Open Access
984 Citations
41,882 Views
28 Pages

Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae

  • Guangling Jiao,
  • Guangli Yu,
  • Junzeng Zhang and
  • H. Stephen Ewart

8 February 2011

Sulfated polysaccharides and their lower molecular weight oligosaccharide derivatives from marine macroalgae have been shown to possess a variety of biological activities. The present paper will review the recent progress in research on the structura...

  • Review
  • Open Access
121 Citations
15,735 Views
22 Pages

27 July 2020

Sprouts and microgreens, the edible seedlings of vegetables and herbs, have received increasing attention in recent years and are considered as functional foods or superfoods owing to their valuable health-promoting properties. In particular, the see...

  • Feature Paper
  • Article
  • Open Access
2,595 Views
24 Pages

Optimized Production and Bioactivities of Protein Hydrolysates from Atlantic Salmon Processing Discards

  • Vegneshwaran Vasudevan Ramakrishnan,
  • Juran Goyali,
  • Deepika Dave and
  • Fereidoon Shahidi

8 June 2025

Enzymatic hydrolysis of Atlantic salmon processing discards, including heads and frames, was carried out using Alcalase, Flavourzyme, and their combination. The degree of hydrolysis varied depending on the enzyme and substrate, ranging from approxima...

  • Review
  • Open Access
7 Citations
2,309 Views
14 Pages

Penicillides from Penicillium and Talaromyces: Chemical Structures, Occurrence and Bioactivities

  • Maria Michela Salvatore,
  • Rosario Nicoletti,
  • Filomena Fiorito and
  • Anna Andolfi

16 August 2024

Penicillide is the founder product of a class of natural products of fungal origin. Although this compound and its analogues have been identified from taxonomically heterogeneous fungi, they are most frequently and typically reported from the species...

  • Review
  • Open Access
72 Citations
9,113 Views
36 Pages

21 October 2022

Edible fungi, commonly known as mushrooms, are precious medicinal and edible homologous gifts from nature to us. Because of their distinctive flavor and exceptional nutritional and medicinal value, they have been a frequent visitor to people’s...

  • Article
  • Open Access
4 Citations
3,081 Views
21 Pages

Chemical Characterization and Bioactivities of Sericin Extracted from Silkworm Cocoons from Two Regions of Portugal

  • Sara Reis,
  • Carina Spencer,
  • Cristina M. Soares,
  • Soraia I. Falcão,
  • Sónia P. Miguel,
  • Maximiano P. Ribeiro,
  • Lillian Barros,
  • Paula Coutinho and
  • Josiana Vaz

Sericin has been characterized as demonstrating a variety of bioactivities, establishing it as a valuable resource for biomedical and pharmaceutical applications. The diverse biological activities of sericin are likely linked to its unique biochemica...

  • Article
  • Open Access
6 Citations
1,769 Views
14 Pages

7 August 2024

Ayocote beans (Phaseolus coccineus L.) are a rich source of some bioactive molecules, such as phenolic compounds that exhibit antioxidant capacity that promote health benefits. Ayocote is mainly consumed after cooking, which can impact the antioxidan...

  • Review
  • Open Access
57 Citations
6,602 Views
24 Pages

Bioactivities of Lipid Extracts and Complex Lipids from Seaweeds: Current Knowledge and Future Prospects

  • Diana Lopes,
  • Felisa Rey,
  • Miguel C. Leal,
  • Ana I. Lillebø,
  • Ricardo Calado and
  • Maria Rosário Domingues

30 November 2021

While complex lipids of seaweeds are known to display important phytochemical properties, their full potential is yet to be explored. This review summarizes the findings of a systematic survey of scientific publications spanning over the years 2000 t...

  • Review
  • Open Access
54 Citations
22,081 Views
26 Pages

Chemical Compounds, Bioactivities, and Applications of Chlorella vulgaris in Food, Feed and Medicine

  • Ana R. Mendes,
  • Maria P. Spínola,
  • Madalena Lordelo and
  • José A. M. Prates

22 November 2024

This review presents the chemical composition, bioactive properties, and diverse applications of Chlorella vulgaris, a green microalga widely recognized for its exceptional nutritional value and therapeutic potential. The study emphasizes the presenc...

  • Article
  • Open Access
6 Citations
2,563 Views
12 Pages

2 July 2023

An apatite-wollastonite glass ceramic (AWGC) has been recognized as one of the popular bioactive materials due to its good osteoconductivity and high mechanical properties in the field of tissue engineering. Various processes have been developed to f...

  • Article
  • Open Access
13 Citations
3,869 Views
16 Pages

13 January 2023

Quinoa proteins are attracting global interest for their wide amino acid profile and as a promising source for the development of biomedical treatments, including those against immune-mediated diseases. However, information about the bioactivity of q...

  • Review
  • Open Access
23 Citations
5,824 Views
26 Pages

27 September 2024

Background/Objectives: At present, a large number of bioactive peptides have been found from plant sources with potential applications for the prevention of chronic diseases. By promoting plant-derived bioactive peptides (PDBPs), we can reduce depend...

  • Review
  • Open Access
53 Citations
5,951 Views
32 Pages

Progress of Bromophenols in Marine Algae from 2011 to 2020: Structure, Bioactivities, and Applications

  • Hui Dong,
  • Songtao Dong,
  • Poul Erik Hansen,
  • Dimitrios Stagos,
  • Xiukun Lin and
  • Ming Liu

4 August 2020

Marine algae contain various bromophenols that have been shown to possess a variety of biological activities, including antiradical, antimicrobial, anticancer, antidiabetic, anti-inflammatory effects, and so on. Here, we briefly review the recent pro...

  • Review
  • Open Access
500 Citations
76,413 Views
26 Pages

22 March 2019

Egg is an encapsulated source of macro and micronutrients that meet all requirements to support embryonic development until hatching. The perfect balance and diversity in its nutrients along with its high digestibility and its affordable price has pu...

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