Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus
AbstractThe phytochemical study on the leaves of Acanthopanax gracilistylus (Araliaceae) resulted in the discovery of a new lupane-triterpene compound, acangraciligenin S (1), and a new lupane-triterpene glycoside, acangraciliside S (2), as well as two known ones, 3α,11α-dihydroxy-lup-20(29)-en-23,28-dioic acid (3) and acankoreoside C (4). Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. The chemical structures of the new compounds 1 and 2 were determined to be 1β,3α-dihydroxy-lup-20(29)-en-23, 28-dioic acid and 1β,3α-dihydroxy-lup-20(29)-en-23,28-dioic acid 28-O-[α-l-rhamnopyranosyl-(1→4)-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl] ester, respectively. The anti-neuroinflammatory activity of the selective compounds, 1 and 3, were evaluated with lipopolysaccharide (LPS)-induced BV2 microglia. The tested compounds showed moderate inhibitory effect of nitric oxide (NO) production. View Full-Text
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Li, X.-J.; Zou, Q.-P.; Wang, X.; Kim, K.-W.; Lu, M.-F.; Ko, S.-K.; Yook, C.-S.; Kim, Y.-C.; Liu, X.-Q. Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus. Molecules 2018, 23, 87.
Li X-J, Zou Q-P, Wang X, Kim K-W, Lu M-F, Ko S-K, Yook C-S, Kim Y-C, Liu X-Q. Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus. Molecules. 2018; 23(1):87.Chicago/Turabian Style
Li, Xiao-Jun; Zou, Qin-Peng; Wang, Xiang; Kim, Kwan-Woo; Lu, Mao-Fang; Ko, Sung-Kwon; Yook, Chang-Soo; Kim, Youn-Chul; Liu, Xiang-Qian. 2018. "Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus." Molecules 23, no. 1: 87.
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